PMID: 11912442Mar 26, 2002Paper

Leydig cell function after cryptorchidism: evidence of the beneficial result of early surgery

The Journal of Urology
Peter A Lee, M T Coughlin

Abstract

We determined whether there are differences indicative of the function of the Leydig cell-pituitary axis in formerly unilateral cryptorchid men. Parameters were compared with those in control men. We determined luteinizing hormone, testosterone, free testosterone, follicle-stimulating hormone, inhibin B, sperm density, motility and morphology, testicular volume, patient weight and age at orchiopexy or at other nonrelated childhood surgery in controls. Significant correlations were noted between hormone levels and other parameters. An inverse correlation between age of surgery and testosterone suggested the detrimental effect of deferring orchiopexy during childhood. Correlations of testosterone with sperm density, motility and morphology suggested a direct relationship between spermatogenesis and testosterone in cryptorchid men. An inverse relationship between body weight and testosterone was observed in each group. There was considerable variation in the range of parameters, sometimes extending into the abnormal range. However, results indicated no differences in mean free testosterone, testosterone or luteinizing hormone in the formerly cryptorchid and control groups, and no difference in time to conception in fertile, former...Continue Reading

Citations

Aug 22, 2009·Der Urologe. Ausg. A·I KörnerW H Rösch
Mar 19, 2004·Current Urology Reports·J C Trussell, Peter A Lee
Oct 19, 2002·Urology·Anuar Ibrahim MitreSami Arap
Jan 12, 2012·BMC Pediatrics·Federico MarchettiUNKNOWN Italian Study Group on Undescended Testes
Nov 16, 2013·Pediatric Surgery International·Emily ChanUNKNOWN FRCSC for Canadian Association of Pediatric Surgeon Evidence-Based Resource
Jun 17, 2003·Clinical Endocrinology·C A de Gouveia BrazaoR F A Weber
Jan 16, 2016·The World Journal of Men's Health·Jae Min Chung, Sang Don Lee
Jul 29, 2005·International Journal of Andrology·Frank H PierikRobertus F A Weber
Jul 25, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Kwan Hyun ParkSang Yong Song

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