PMID: 6984293Dec 1, 1982Paper

Leydig cells nonspecifically suppress lymphoproliferation in vitro: implications for the testis as an immunologically privileged site

American Journal of Reproductive Immunology : AJRI
W Born, H Wekerle

Abstract

We have studied the influence of mouse testis cells on unstimulated lymphoproliferation; on allogeneic mixed lymphocyte reaction; and on concanavalin A-stimulated, phytohemagglutinin-stimulated, or lipopolysaccaride-stimulated responses in vitro. Co-culture with highly enriched irradiated (2000 R) Leydig cells (LC) led in each case to a considerable reduction of 3H TdR uptake. Prolonged tissue graft survival times suggest that the testis is an immunologically privileged site. This may be explained by an immune-suppressive function of LC in vivo. LC are also capable of selectively binding lymphoid and myeloid cells to their surface. This capacity, accompanied by a suppression of immune reactivity in situ, may play a role in cases of testicular relapse observed in acute leukemia.

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Citations

Nov 1, 1988·Journal of Reproductive Immunology·P PöllänenJ Uksila
Aug 1, 1990·Journal of Reproductive Immunology·V Wicher, K Wicher
May 1, 1994·Journal of Reproductive Immunology·P Pöllänen, T G Cooper
Jul 1, 1997·Journal of Reproductive Immunology·S Sainio-PöllänenP Pöllänen
Aug 1, 1991·International Journal of Andrology·M EmotoS Kashiba
Oct 22, 2013·Journal of Reproductive Immunology·Robert De RoseWendy R Winnall
Aug 11, 1991·Journal of Pediatric Surgery·E M BarksdaleP K Donahoe
Oct 1, 1989·American Journal of Reproductive Immunology : AJRI·M EmotoS Kashiba
Jun 14, 2013·Systems Biology in Reproductive Medicine·Elumalai PrithivirajSeppan Prakash
Mar 7, 2014·Systems Biology in Reproductive Medicine·Prakash Seppan, Kamakshi Krishnaswamy
Jun 13, 1998·The Anatomical Record·M ItohY Takeuchi
Feb 1, 1988·Immunology and Cell Biology·S Maddocks, B P Setchell
Mar 1, 1993·Cell Transplantation·H P Selawry, D F Cameron
Jan 1, 1988·The Journal of Urology·M B StatterP K Donahoe
Apr 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·C A Mahi-BrownK S Tung

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