LFA-1 and MAC-1 mediate pulmonary recruitment of neutrophils and tissue damage in abdominal sepsis

Shock
Muhammad AsaduzzamanHenrik Thorlacius

Abstract

Neutrophil-mediated lung damage is an insidious feature in septic patients, although the adhesive mechanisms behind pulmonary recruitment of neutrophils in polymicrobial sepsis remain elusive. The aim of the present study was to define the role of lymphocyte function antigen-1 (LFA-1) and membrane-activated complex 1 (Mac-1) in septic lung injury. Pulmonary edema, bronchoalveolar infiltration of neutrophils, levels of myeloperoxidase, and CXC chemokines were determined after cecal ligation and puncture (CLP). Mice were treated with monoclonal antibodies directed against LFA-1 and Mac-1 before CLP induction. Cecal ligation and puncture induced clear-cut pulmonary damage characterized by edema formation, neutrophil infiltration, and increased levels of CXC chemokines in the lung. Notably, immunoneutralization of LFA-1 or Mac-1 decreased CLP-induced neutrophil recruitment in the bronchoalveolar space by more than 64%. Moreover, functional inhibition of LFA-1 and Mac-1 abolished CLP-induced lung damage and edema. However, formation of CXC chemokines in the lung was intact in mice pretreated with the anti-LFA-1 and anti-Mac-1 antibodies. Our data demonstrate that both LFA-1 and Mac-1 regulate pulmonary infiltration of neutrophils an...Continue Reading

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Citations

May 22, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M ChewH Thorlacius
Dec 31, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michelle S ChewHenrik Thorlacius
Feb 22, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Milladur RahmanHenrik Thorlacius
Nov 28, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J RollerH Thorlacius
Dec 25, 2012·The Journal of Surgical Research·James E FisherScott L Nyberg
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Oct 1, 2010·The British Journal of Surgery·A AbdullaH Thorlacius
Jan 20, 2011·British Journal of Pharmacology·Darbaz AwlaHenrik Thorlacius
Dec 3, 2014·European Journal of Pharmacology·Changhui YuHenrik Thorlacius
Mar 1, 2012·European Journal of Pharmacology·Karzan PalaniHenrik Thorlacius
Feb 6, 2013·European Journal of Pharmacology·Yongzhi WangHenrik Thorlacius
Nov 12, 2013·The American Journal of Pathology·Mark J MondrinosLaurie E Kilpatrick
May 18, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Erik WetterholmHenrik Thorlacius
May 18, 2016·Journal of Diabetes Investigation·Juan HuangZhiguang Zhou
Jan 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yao-Wen ChangPei-Wen Hsieh
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Jul 12, 2019·Journal of Applied Physiology·Alexandre GaudetNathalie De Freitas Caires
Nov 19, 2019·Frontiers in Immunology·Avin HawezHenrik Thorlacius
Sep 19, 2015·World Journal of Clinical Cases·Jia-Ren LiuKoichi Yuki
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Nazli Alizadeh-TabriziChristian Lehmann
Jul 31, 2014·Shock·Jia-Ren LiuKoichi Yuki
Aug 19, 2008·Shock·Christoph Thiemermann
Jun 12, 2021·Journal of Leukocyte Biology·Avin HawezHenrik Thorlacius

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