LFR is functionally associated with AS2 to mediate leaf development in Arabidopsis

The Plant Journal : for Cell and Molecular Biology
Xiaowei LinSujuan Cui

Abstract

Leaves are essential organs for plants. We previously identified a functional gene possibly encoding a component of the SWI/SNF complex named Leaf and Flower Related (LFR) in Arabidopsis thaliana. Loss-of-function mutants of LFR displayed obvious defects in leaf morphogenesis, indicating its vital role in leaf development. Here an allelic null mutant of ASYMMETRIC LEAVES2 (AS2), as2-6, was isolated as an enhancer of lfr-1 in petiole length, vasculature pattern and leaf margin development. The lfr as2 double-mutants showed enhanced ectopic expression of BREVIPEDICELLUS (BP) compared with each of the single-mutants, which is consistent with their synergistic genetic enhancement in multiple BP-dependent development processes. Moreover, LFR and several putative subunits of the SWI/SNF complex interacted physically with AS2. LFR associated with BP chromatin in an AS1-AS2-dependent manner to promote the nucleosome occupancy for appropriate BP repression in leaves. Taken together, our findings reveal that LFR and the SWI/SNF complex play roles in leaf development at least partly by repressing BP transcription as interacting factors of AS2, which expounds our understanding of BP repression at the chromatin structure level in leaf devel...Continue Reading

References

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J CôtéJ L Workman
Feb 27, 1999·Current Opinion in Plant Biology·A Hudson
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Jun 18, 2002·Plant Physiology·Bin ShuaiPatricia S Springer
Nov 6, 2002·The Plant Cell·Mande K KumaranVenkatesan Sundaresan
Jun 6, 2003·The Plant Journal : for Cell and Molecular Biology·Miki NakazawaMinami Matsui
Feb 12, 2004·The Plant Journal : for Cell and Molecular Biology·Aviva KatzNir Ohad
May 26, 2006·Plant Molecular Biology·Simon Scofield, James A H Murray
Jun 15, 2007·Trends in Genetics : TIG·Chang Seob Kwon, Doris Wagner
Jan 22, 2008·The Plant Cell·Mengjuan GuoMarja C P Timmermans
Sep 13, 2008·Trends in Plant Science·Lukasz KnizewskiAndrzej Jerzmanowski
Dec 23, 2008·Current Biology : CB·Lin Xu, Wen-Hui Shen
Jan 13, 2009·Journal of Bioscience and Bioengineering·Hiro TakahashiTakeshi Kobayashi
Apr 10, 2009·Annual Review of Biochemistry·Cedric R Clapier, Bradley R Cairns
Jul 28, 2009·Current Opinion in Plant Biology·Angela Hay, Miltos Tsiantis
Sep 28, 2010·Current Opinion in Plant Biology·Jihyun Moon, Sarah Hake
Nov 26, 2010·Plant & Cell Physiology·Gorou HoriguchiHirokazu Tsukaya
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Miin-Feng WuDoris Wagner
Mar 3, 2012·The Plant Journal : for Cell and Molecular Biology·Ziyu LiAiwu Dong
Mar 22, 2014·The Arabidopsis Book·Nobutoshi YamaguchiDoris Wagner

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Aug 19, 2020·The Plant Journal : for Cell and Molecular Biology·Dongmei QiSujuan Cui

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