LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention

Oncogene
Pavlos StampolidisStefano Iacobelli

Abstract

The extracellular matrix protein lectin galactoside-binding soluble 3 binding protein (LGALS3BP) constitutes a negative prognostic marker of cancer onset and progression with increasing value in clinical application. Since its discovery, however, although the glycoprotein has been implicated in a growing number of disease-related processes, its actual role and mechanism of action have remained ambiguous, thus hindering opportunities for therapeutic development. In this study, we have determined that LGALS3BP constitutes a novel ligand for integrins α1β1, α5β1, αvβ1 and α6β1 and have identified that these newly established partnerships at the membrane level are responsible for exerting the molecule's involvement in cancer through manipulation of multiple canonical 'outside-in' integrin signalling events. We demonstrate that LGALS3BP-mediated integrin activation results into signal transmission via Akt, JNK and the Ras cascade via the Raf-ERK axis while p38 activity is kept at baseline levels. Transient cellular adherence to LGALS3BP favours survival and proliferation signalling while apoptosis is kept at bay. Sustained cellular exposure to LGALS3BP significantly supports viability, motility and migration. Importantly, an anti-LG...Continue Reading

References

Jan 1, 1994·British Journal of Cancer·S IacobelliC Natoli
May 5, 1999·Journal of Clinical Immunology·P PellicciaS Iacobelli
Feb 17, 2000·Cellular Signalling·K Ono, J Han
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S C DreskinL E Heasley
Jan 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·P A IacovazziM Correale
Aug 8, 2002·The Journal of Investigative Dermatology·Anna Maria CesinaroGian Paolo Trentini
Mar 15, 2003·Nature Reviews. Cancer·John D Hood, David A Cheresh
Jul 16, 2003·Cellular and Molecular Life Sciences : CMLS·C Rüegg, A Mariotti
Oct 15, 2003·Arthritis and Rheumatism·Shiro OhshimaMichel Neidhart
Feb 6, 2004·Glycoconjugate Journal·Antonino GrassadoniaStefano Iacobelli
Sep 21, 2004·Cancer·Jens KoopmannAnirban Maitra
Mar 7, 2006·Journal of Cellular Biochemistry·Tricia A UlmerSuzanne Laferté
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Yuk Pheel ParkHee Gu Lee
Jun 1, 2007·Molecular Carcinogenesis·Ann M Bode, Zigang Dong
Jun 28, 2008·Drug Discovery Today·Julie Huxley-JonesMichael R Barnes
Sep 18, 2008·Journal of Translational Medicine·Hua XueMaode Lai
Dec 17, 2008·Cancer Chemotherapy and Pharmacology·Flaubert Mbeunkui, Donald J Johann
Feb 28, 2009·Methods in Molecular Biology·Paul A Mould
May 9, 2009·International Journal of Oncology·Severine Van SlambrouckWim F A Steelant
Jun 25, 2009·Pharmacological Reviews·Hannu JärveläinenRisto Penttinen
Aug 21, 2009·Cell and Tissue Research·Malgorzata BarczykDonald Gullberg
Dec 8, 2009·Science·Richard O Hynes
Dec 19, 2009·Molecular & Cellular Proteomics : MCP·Rajaventhan SrirajaskanthanNicholas J Beaumont
Nov 11, 2010·Journal of Cell Science·Patricia A EisenachWilliam R English
Mar 29, 2011·Cold Spring Harbor Perspectives in Biology·Benjamin Geiger, Kenneth M Yamada
Sep 2, 2011·Pharmacological Reviews·Vanesa Gabriela MartínezFrancisco Lozano
Sep 24, 2011·Journal of Oncology·Stephan Niland, Johannes A Eble
Dec 14, 2011·Current Protocols in Cell Biology·A Paul Mould
Feb 22, 2012·The Journal of Cell Biology·Pengfei LuZena Werb
May 29, 2012·Trends in Pharmacological Sciences·Simon L Goodman, Martin Picard
Aug 7, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Enza PiccoloStefano Iacobelli
Mar 19, 2013·Journal of Experimental & Clinical Cancer Research : CR·Niranjan AwasthiRoderich E Schwarz

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Citations

Feb 16, 2016·Cellular Signalling·Myoungkun JeoungEmilia Galperin
Sep 13, 2015·Journal of Proteomics·Kathrin Grundner-CulemannHenrik Daub
Nov 20, 2016·Journal of Cellular Biochemistry·Carol P Y LauShekhar Madhukar Kumta
Jan 3, 2020·International Journal of Oncology·Ryuichiro KimuraToyomasa Katagiri
Mar 16, 2018·Oncotarget·Maria Garranzo-AsensioRodrigo Barderas
Oct 28, 2019·Scientific Reports·Maria HarmatiKrisztina Buzas
Dec 23, 2016·Journal of Gastroenterology and Hepatology·Yuki BekkiYoshihiko Maehara
Jun 28, 2019·Current Medicinal Chemistry·María Garranzo-AsensioAna Guzman-Aranguez
May 31, 2021·Archives of Oral Biology·Lingpeng ZhangHongbin Yu
Sep 28, 2021·Journal of Translational Medicine·Emily CaponeGianluca Sala
Nov 4, 2021·Nature Communications·Christina KyrousiSilvia Cappello

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