Lgr4 controls specialization of female gonads in mice

Biology of Reproduction
Masae KoizumiKatsuhiko Nishimori

Abstract

Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a type of membrane receptor with a seven-transmembrane structure. LGR4 is homologous to gonadotropin receptors, such as follicle-stimulating hormone receptor (Fshr) and luteinizing hormone/choriogonadotropin receptor (Lhcgr). Recently, it has been reported that Lgr4 is a membrane receptor for R-spondin ligands, which mediate Wnt/beta-catenin signaling. Defects of R-spondin homolog (Rspo1) and wingless-type MMTV integration site family, member 4 (Wnt4) cause masculinization of female gonads. We observed that Lgr4(-/-) female mice show abnormal development of the Wolffian ducts and somatic cells similar to that in the male gonads. Lgr4(-/-) female mice exhibited masculinization similar to that observed in Rspo1-deficient mice. In Lgr4(-/-) ovarian somatic cells, the expression levels of lymphoid enhancer-binding factor 1 (Lefl) and Axin2 (Axin2), which are target genes of Wnt/beta-catenin signaling, were lower than they were in wild-type mice. This study suggests that Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 and Wnt/beta-catenin.

References

Aug 6, 1970·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Jost
Jan 1, 1995·Vitamins and Hormones·L D KohnM Saji
Apr 29, 1998·Annual Review of Physiology·M L Dufau
Jan 23, 2004·The New England Journal of Medicine·David T MacLaughlin, Patricia K Donahoe
Jun 21, 2006·Nephron. Experimental Nephrology·Shigeki KatoKatsuhiko Nishimori
Oct 17, 2006·Nature Genetics·Pietro ParmaGiovanna Camerino
May 26, 2007·Reproduction, Fertility, and Development·Lenka A VodstrcilLaura J Parry
Aug 21, 2007·General and Comparative Endocrinology·Tom Van LoyJozef Vanden Broeck
Sep 14, 2007·FEBS Letters·Shigeki KatoKatsuhiko Nishimori
Feb 6, 2008·Human Molecular Genetics·Kazuma TomizukaMakoto Kakitani
Feb 6, 2008·Human Molecular Genetics·Anne-Amandine ChassotMarie-Christine Chaboissier
Nov 26, 2008·Trends in Genetics : TIG·Ryohei Sekido, Robin Lovell-Badge
Dec 17, 2009·Cell·N Henriette UhlenhautMathias Treier
Feb 11, 2010·The Journal of Steroid Biochemistry and Molecular Biology·K M McNamaraD J Handelsman
Jun 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kendra S CarmonQingyun Liu
Oct 24, 2012·PloS One·Danielle M MaatoukBlanche Capel
May 30, 2013·Development·Nick BarkerHans Clevers
Aug 27, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mizuki SoneKatsuhiko Nishimori
Jul 7, 2014·Nature Cell Biology·Annie NgNick Barker
Aug 27, 2014·Developmental Biology·Raphael H RastetterDagmar Wilhelm
Sep 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Anne-Amandine ChassotMarie-Christine Chaboissier

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Citations

May 31, 2016·Progress in Biophysics and Molecular Biology·Gui-Xun ShiLei-Sheng Jiang
May 18, 2018·Nature·Emmanuelle Szenker-RaviBruno Reversade
Aug 31, 2017·Annual Review of Genetics·Cassy SpillerJosephine Bowles
Feb 6, 2016·Clinical Science·Ingrid KnarstonAndrew Sinclair
Dec 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhiying YueMingyao Liu
Mar 28, 2019·Bioscience, Biotechnology, and Biochemistry·Ayano OtsukaKatsuhiko Nishimori
May 18, 2018·Endocrine Reviews·Emmi RotgersHumphrey Hung-Chang Yao
May 6, 2021·International Journal of Molecular Sciences·Alejandro Ordaz-RamosKarla Vazquez-Santillan
Jun 18, 2021·International Immunopharmacology·Baoyi YinGanzhen Deng

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