LGR5 overexpression confers poor relapse-free survival in breast cancer patients

BMC Cancer
Ming-Feng HouPei-Yi Chu

Abstract

Cancer stem cells (CSCs) are believed to promote the malignant transformation of breast cancer via multiple signaling pathways, including the Wnt/β-catenin pathway. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has been identified as a CSC-associated Wnt-regulated target gene, but its clinical significance in the context of breast cancer remains elusive. Therefore, the purpose of this study was to investigate the clinical significance of the LGR5-β-catenin axis in breast cancer. Breast cancer tissue blocks from 126 patients were used to construct a tissue microarray (TMA). Histopathological and clinical data including age; tumor size; estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) level; tumor grade; lymph node (LN) status; and survival were obtained from the cancer registry database and patients' medical records. Tissue on the breast TMA was scored for LGR5 and β-catenin expression using semi-quantitative immunohistochemical (IHC) staining. We also analyzed LGR5 expression in cellular datasets available through ONCOMINE, a web-based cancer microarray database. Immunohistochemical staining revealed that 58 tumors (46%) exhibited high LGR5 expression, ...Continue Reading

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Citations

Feb 23, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Yongning JiaJiafu Ji
Mar 27, 2020·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Dec 24, 2018·International Journal of Molecular Sciences·Júlia Vallvé-JuanicoXavier Santamaria
Jul 17, 2020·Journal of Cancer Research and Clinical Oncology·Arkadiusz GzilŁukasz Szylberg
May 28, 2019·International Journal of Environmental Research and Public Health·Chih-Jan KoPei-Yi Chu
Feb 23, 2020·Frontiers in Cell and Developmental Biology·Emma H van Schie, Renée van Amerongen
Dec 15, 2020·World Journal of Stem Cells·Xu Gao, Qiong-Zhu Dong
Mar 16, 2021·Frontiers in Immunology·Nicholas B BlackburnJoanne E Curran

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Methods Mentioned

BETA
surgical resection

Software Mentioned

ONCOMINE
SPSS

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