PMID: 2116944Jun 1, 1990Paper

LH and FSH secretion and responses to GnRH and TRH in patients with clinically functionless pituitary adenomas

Clinical Endocrinology
M C WhiteA P Murdoch

Abstract

Serum concentrations of LH and FSH and their response to the separate administration of GnRH (100 micrograms i.v.) and TRH (200 micrograms i.v.) have been studied preoperatively in 12 patients with a clinically functionless pituitary adenoma, of whom nine (3F: 6M) were found to secrete gonadotrophins in vitro. In three patients with a gonadotrophin-secreting adenoma (GSA) the pulsatile release of LH and FSH was also assessed preoperatively. An elevated serum FSH was recorded in six of nine patients with a GSA, and was subnormal in one, whilst an elevated LH was recorded in only two and was subnormal in six. A doubling of LH occurred in only four of the nine patients after GnRH and in three of six after TRH. None of the three patients with a non-GSA was shown to have an aberrant response to GnRH or TRH. In patients with a GSA, pulsatile release of LH and FSH was usually asynchronous and neither hormone demonstrated any regular harmonic pattern. These data show that in patients with a GSA the serum FSH level is usually elevated but this is not invariable, and the LH may well be low. Pathological responses of LH are frequently found following the administration of either GnRH or TRH and these stimulation tests should be performed ...Continue Reading

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Citations

Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Shomali, L Katznelson
Feb 28, 1991·The New England Journal of Medicine·L DaneshdoostP J Snyder
Dec 1, 1994·Clinical Endocrinology·E A WilliamsonP E Harris
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·G Faglia
Jun 1, 1992·Journal of Endocrinological Investigation·B AmbrosiG Faglia

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