PMID: 2509619Oct 1, 1989Paper

LHRH pulse frequency in normal and infertile men

The Journal of Endocrinology
F C WuR E Sellar

Abstract

The aim of this study was to examine the hypothesis that decreased LHRH pulse frequency may be responsible for the preferential rise in FSH in infertile men. The LH pulse pattern was determined as an index of hypothalamic LHRH secretion in 21 infertile patients with idiopathic azoospermia or oligoasthenozoospermia and 14 fertile age-matched controls by frequent blood sampling at 10-min intervals for 24 h. The infertile patients were further divided into three groups according to their relative concentrations of FSH and LH: (1) normal FSH and LH, (2) raised FSH but normal LH, and (3) raised FSH and LH. LH pulses were detected by a computerized algorithm (Munro) validated against a threshold method. Concentrations of FSH, testosterone, sex hormone-binding globulin and oestradiol were measured in pooled plasma. Luteinizing hormone pulse frequencies in normal men were not significantly different from the infertile group as a whole. Similarly, mean LH pulse frequencies in infertile subgroups 1, 2 and 3 were not significantly lower than normal. Pulse interval, however, was increased in subgroup 1 compared with normal. Mean 24 h LH in group 2 was significantly higher than normal, but still within the normal range. The total testostero...Continue Reading

Citations

Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·F C Wu
Dec 1, 1990·Clinical Endocrinology·R M Sharpe
Nov 14, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·Y KojimaM Okabe
Sep 6, 2006·The Journal of Urology·Rajeev KumarNarmada P Gupta
May 1, 1991·The Veterinary Clinics of North America. Small Animal Practice·V N Meyers-Wallen

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