Abstract
To evaluate the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) v2017 major features, the impact of ancillary features, and categories on contrast-enhanced computed tomography (CECT) for the diagnosis of hepatocellular carcinoma (HCC). This retrospective study included 59 patients (104 observations including 72 HCCs) with clinical suspicion of HCC undergoing CECT between 2013 and 2016. Two radiologists independently assessed major and ancillary imaging features for each liver observation and assigned a LI-RADS category based on major features only and in combination with ancillary features. The composite reference standard included pathology or imaging. Per-lesion estimates of diagnostic performance of major features, ancillary features, and LI-RADS categories were assessed by generalized estimating equation models. Major features (arterial phase hyperenhancement, washout, capsule, and threshold growth) respectively had a sensitivity of 86.1%, 81.6%, 20.7%, and 26.1% and specificity of 39.3%, 67.9%, 89.9%, and 85.0% for HCC. Ancillary features (ultrasound visibility as discrete nodule, subthreshold growth, and fat in mass more than adjacent liver) respectively had a sensitivity of 42.6%, 50.8%, and 1...Continue Reading
References
Jul 1, 1996·AJR. American Journal of Roentgenology·J H OliverH E Rockette
Feb 4, 2003·Radiology·Andrea LaghiRoberto Passariello
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marta BurrelUNKNOWN Barcelona Clínic Liver Cancer Group
Jun 15, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luigi BolondiFabio Piscaglia
Dec 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alejandro FornerJordi Bruix
Nov 13, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Timm DeneckeEnrique Lopez Hänninen
Dec 3, 2009·Gut·Angelo SangiovanniMassimo Colombo
Aug 3, 2010·Journal of Magnetic Resonance Imaging : JMRI·Asra S KhanJorge A Marrero
Sep 10, 2010·Hepatology International·Masao OmataShiv Kumar Sarin
Jun 28, 2011·AJR. American Journal of Roentgenology·Young Joo SuhKi Whang Kim
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixCarmen Ayuso
Oct 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas SerstéFrançoise Degos
Feb 9, 2012·Journal of Hepatology·Jordi RimolaJordi Bruix
Nov 10, 2012·European Radiology·Chansik AnKi Whang Kim
May 2, 2013·Journal of Clinical Gastroenterology·Sahil Mittal, Hashem B El-Serag
Jul 26, 2013·AJR. American Journal of Roentgenology·Hyun-Jung JangMorris Sherman
Jun 1, 2012·Liver Cancer·Jeong Min LeeHyun Sik Woo
Sep 24, 2014·Radiology·Jin-Young ChoiClaude B Sirlin
Nov 6, 2014·Journal of Magnetic Resonance Imaging : JMRI·Mustafa R BashirTracy A Jaffe
Feb 7, 2015·Radiology·Anna DarnellJordi Bruix
May 20, 2015·Annals of Internal Medicine·Roger ChouSean D Sullivan
Jun 30, 2015·Journal of Magnetic Resonance Imaging : JMRI·Yu-Dong ZhangHai-Bin Shi
Feb 3, 2016·Abdominal Radiology·Robert F HannaClaude B Sirlin
Apr 8, 2016·Abdominal Radiology·Marco Dioguardi BurgioGiuseppe Brancatelli
May 20, 2016·Abdominal Radiology·Eric C EhmanThomas A Hope
Jul 31, 2016·Journal of Magnetic Resonance Imaging : JMRI·Ijin JooJoon Koo Han
Jan 29, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie K HeimbachJorge A Marrero
Aug 31, 2017·Radiology·Tyler J FraumKathryn J Fowler
Nov 2, 2017·Radiology·Kathryn J FowlerClaude B Sirlin
Nov 14, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Khaled M ElsayesClaude B Sirlin
Nov 23, 2017·Radiology·An TangUNKNOWN LI-RADS Evidence Working Group
Dec 24, 2017·Journal of Hepatology·Maxime RonotValérie Vilgrain
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Apr 11, 2018·Radiology·Milena CernyAn Tang
Sep 27, 2018·Journal of Magnetic Resonance Imaging : JMRI·Andrea S KieransElizabeth M Hecht
Citations
Jan 16, 2020·Journal of Computer Assisted Tomography·Ahmed Abdel Khalek Abdel RazekWalaa Shabana
Mar 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Sunyoung LeeMyeong-Jin Kim
Jun 20, 2019·Journal of Magnetic Resonance Imaging : JMRI·Khaled M ElsayesClaude B Sirlin
Oct 2, 2020·European Radiology·Dong Hwan KimJoon-Il Choi
Feb 29, 2020·European Radiology·Roberto CannellaAlessandro Furlan
Jun 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Gaurav KhatriTakeshi Yokoo
Dec 6, 2019·Hepatology International·Sunyoung LeeDonald G Mitchell
Mar 7, 2021·Diagnostics·Lingling LiJianhua Zhou
Mar 14, 2021·European Radiology·Ji Hun KangJae Ho Byun
Jun 3, 2021·Biology·Cosmin CaraianiChristoph Dietrich
Aug 24, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Takamichi MurakamiMasatoshi Hori
Sep 15, 2021·Abdominal Radiology·Roberta CataniaAlessandro Furlan
Sep 29, 2021·Radiology·Jae Seok BaeHaeryoung Kim
Oct 7, 2021·The Cochrane Database of Systematic Reviews·Tin NadarevicDavor Štimac
Nov 17, 2021·Radiology·Christian B van der PolTakeshi Yokoo
Nov 21, 2021·Abdominal Radiology·Yang HuangWei Wang