Lichen Biosynthetic Gene Clusters. Part I. Genome Sequencing Reveals a Rich Biosynthetic Potential

Journal of Natural Products
Robert L BertrandJohn L Sorensen

Abstract

Lichens are symbionts of fungi and algae that produce diverse secondary metabolites with useful properties. Little is known of lichen natural product biosynthesis because of the challenges of working with lichenizing fungi. We describe the first attempt to comprehensively profile the genetic secondary metabolome of a lichenizing fungus. An Illumina platform combined with the Antibiotics and Secondary Metabolites Analysis Shell (FungiSMASH, version 4.0) was used to sequence and annotate assembled contigs of the fungal partner of Cladonia uncialis. Up to 48 putative gene clusters are described comprising type I and type III polyketide synthases (PKS), nonribosomal peptide synthetases (NRPS), hybrid PKS-NRPS, and terpene synthases. The number of gene clusters revealed by this work dwarfs the number of known secondary metabolites from C. uncialis, suggesting that lichenizing fungi have an unexplored biosynthetic potential.

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Citations

Feb 11, 2020·Frontiers in Microbiology·Jorge Carlos Navarro-Muñoz, Jérôme Collemare
Sep 13, 2018·Journal of Industrial Microbiology & Biotechnology·Robert L Bertrand, John L Sorensen
Jul 17, 2018·Biochemical and Biophysical Research Communications·Mona E Abdel-HameedJohn L Sorensen
Mar 12, 2021·Genome Biology and Evolution·Gulnara TagirdzhanovaToby Spribille
May 26, 2021·Planta medica·Isabel Ureña-VacasM Pilar Gómez-Serranillos
Feb 28, 2018·Journal of Natural Products·Robert L BertrandJohn L Sorensen

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