Lichen planopilaris and pseudopelade of Brocq involve distinct disease associated gene expression patterns by microarray

Journal of Dermatological Science
Mei YuKevin J McElwee

Abstract

Lichen planopilaris (LPP) and pseudopelade of Brocq (PPB) are two scarring alopecia diagnoses that exhibit similar clinical features. Some suggest LPP and PPB are not distinct diseases, but rather different clinical presentations in a spectrum derived from the same underlying pathogenic mechanism. We explored the degree of similarity between LPP and PPB gene expression patterns and the potential for common and unique gene pathway and gene activity in LPP and PPB using microarrays. Microarray analysis, using a 21K cDNA set, was performed on pairs of biopsies obtained from affected and unaffected scalp of untreated patients. Diagnosis was confirmed by histopathology. Significantly differentially expressed genes were identified by analysis of microarray results in various datasets and screened for signaling pathway involvement. Selected genes were validated by quantitative PCR and immunohistology. The global gene expression profiles in LPP and PPB versus comparative intra-control scalp tissue were distinguishable by significance analysis of microarrays (SAM). There was limited commonality in the gene expression profiles between LPP and PPB. Specific genes, such as MMP11, TNFSF13B, and APOL2, were identified with significantly diff...Continue Reading

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Apr 13, 2012·American Journal of Clinical Dermatology·Franco Rongioletti, Konstantina Christana
Aug 27, 2013·Indian Journal of Dermatology, Venereology and Leprology·Sunil Dogra, Rishu Sarangal
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