PMID: 11318033Apr 25, 2001Paper

Lichenysin: a more efficient cation chelator than surfactin

Applied Biochemistry and Biotechnology
I GrangemardF Peypoux

Abstract

The lipopeptide lichenysin (cyclo-[L-Gln1-->D-Leu2-->L-Leu3-->L-Val4--> L-Asp5-->D-Leu6-->L-Ile7-beta-OH fatty acid]) produced by Bacillus licheniformis structurally resembles surfactin from Bacillus subtilis. The main difference is the presence of a glutaminyl residue in position 1 of the peptide sequence in place of glutamic acid in surfactin. This local variation causes significant changes in the properties of the molecule compared to surfactin. Lichenysin has a higher surfactant power, the critical micellar concentration (c.m.c.) being strongly reduced from 220 to 22 microM and a much higher hemolytic activity because 100% hemolysis was observed with only 15 microM instead of 200 microM. Lichenysin is also a better chelating agent because its association constants with Ca2+ and Mg2+ are increased by a factor of 4 and 16, respectively. This effect is assigned to an increase in the accessibility of the carboxyl group to cations owing to a change in the side chain topology induced by the Glu/Gln exchange. Additionally, the propensity of the lipopeptide for extensive hydrophobic interactions, as illustrated by its low c.m.c., contributes to further stabilization of the cation and an increase in the partitioning of lichenysin in...Continue Reading

Citations

Apr 29, 2010·Applied Microbiology and Biotechnology·Ibrahim M BanatRoger Marchant
May 18, 2010·Applied Microbiology and Biotechnology·Xiangyang LiuLixin Zhang
Apr 30, 2011·Biotechnology Letters·Estibaliz Sansinenea, Aurelio Ortiz
Aug 1, 2012·Journal of the American Society for Mass Spectrometry·Khyati V PathakPadmanabhan Balaram
Dec 15, 2010·International Journal of Molecular Sciences·Pornpimon KanjanavasKosum Chansiri
Feb 23, 2011·International Journal of Molecular Sciences·Niran RoongsawangMasaaki Morikawa
Aug 6, 2005·Biotechnology Progress·Mao-Sung YehJo-Shu Chang
Dec 15, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jonathan R CoronelAntonio Ortiz
Jan 9, 2016·Current Microbiology·Anila Fariq, Ayesha Saeed
Feb 19, 2008·Mycological Research·B Gillian TurgeonKathryn Bushley
Mar 2, 2005·Trends in Microbiology·Jacques Ravel, Claire M Fraser
Jul 22, 2014·Environmental Microbiology·Isabelle BenoitÁkos T Kovács
Apr 24, 2010·FEMS Microbiology Reviews·Jos M RaaijmakersMarc Ongena
May 2, 2016·Applied Biochemistry and Biotechnology·Harish Suthar, Anuradha Nerurkar
Sep 29, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Helene Thorsen RønningPer Einar Granum
May 29, 2014·Medicinal Research Reviews·Stephen A Cochrane, John C Vederas
Mar 24, 2015·Chemical Communications : Chem Comm·Ian W Hamley
Feb 14, 2006·The Journal of Antimicrobial Chemotherapy·Lígia RodriguesRosário Oliveira
May 11, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yong MengBo-Zhong Mu
Jun 12, 2017·Applied Microbiology and Biotechnology·Chengjun ZhuShouwen Chen
Mar 14, 2021·Colloids and Surfaces. B, Biointerfaces·Yuhan YanChunguang Ren
Mar 20, 2021·Frontiers in Bioengineering and Biotechnology·Ariane ThéatrePhilippe Jacques
Mar 30, 2021·Computational and Structural Biotechnology Journal·Carolina Gutiérrez-ChávezBelinda C Ferrari
Jul 27, 2021·Bioresource Technology·Zhiwen ZhuBing Chen
Aug 29, 2017·ACS Chemical Biology·Sebastian GötzePierre Stallforth

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.