Abstract
Licochalcone A (LA) has been shown to exert multiple pharmacological effects, including anti-inflammatory, antiparasitic, antifungal, anticancer, and osteogenic activities. The present study investigated the ability of LA to suppress the differentiation of 3T3-L1 preadipocytes, and its antiobesity activity was explored using high fat diet (HFD)-fed ICR mice. During the terminal differentiation process, 3T3-L1 preadipocytes were treated with LA, and the lipid contents were quantified along with any changes in the expression of biomarkers associated with adipocyte differentiation and lipogenesis. The results show that LA significantly reduced lipid accumulation and down-regulated the expression of peroxisome proliferator-activated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1c, and their target genes (fatty acid binding protein, fatty acid synthase, stearoyl-CoA desaturase 1, and glycerol-3-phosphate acyltransferase). In an animal study, body weight, triglyceride, cholesterol, and nonesterified fatty acid levels in the group given 10 mg/kg LA were significantly decreased by 14.0, 48.2, 58.9, and 73.5%, respectively. Transverse microcomputed tomography indicated that visceral fat depots ...Continue Reading
References
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Nov 18, 2000·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·S Shibata
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
May 29, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Philip T JamesUNKNOWN International Obesity Task Force
Dec 30, 2004·Diabetes/metabolism Research and Reviews·Joel R L EhrenkranzJesse Roth
Jun 7, 2005·Nature Medicine·Gema Medina-Gomez, Antonio Vidal-Puig
Jan 3, 2006·Annals of the New York Academy of Sciences·Fumika Mi-IchiKiyoshi Kita
Mar 23, 2006·Archives of Dermatological Research·Ludger KolbeHorst Wenck
Nov 23, 2006·European Journal of Medicinal Chemistry·Zdzisława Nowakowska
Apr 12, 2007·Archives of Pharmacal Research·Goo YoonSeung Hoon Cheon
Jun 20, 2007·Circulation·Caroline S FoxChristopher J O'Donnell
Aug 2, 2007·Critical Pathways in Cardiology·Jean-Pierre Després
Oct 25, 2007·Cell·Stephane GestaC Ronald Kahn
May 20, 2008·Medical Engineering & Physics·Y K LuuS Judex
May 23, 2008·The Journal of Nutritional Biochemistry·Srujana RayalamClifton A Baile
Sep 30, 2008·Obesity·B Selma MohammedSamuel Klein
Mar 28, 2009·PLoS Computational Biology·Junghyo JoVipul Periwal
Jun 16, 2009·Methods : a Companion to Methods in Enzymology·S JudexC T Rubin
Jul 30, 2009·Mycoses·C TangjaturonrusameeA Tosti
Feb 16, 2010·International Immunopharmacology·Megumi Funakoshi-TagoTadashi Kasahara
May 13, 2010·Biological & Pharmaceutical Bulletin·Yeon Sil LeeSoon Sung Lim
Jul 20, 2010·Biochemical Pharmacology·Yoon Hee KimJin-Kyung Kim
Nov 3, 2010·Mini Reviews in Medicinal Chemistry·H B Vaidya, R K Goyal
Apr 7, 2011·Amino Acids·Soon Nam KimSeong Hwan Kim
May 28, 2011·Mycoses·Céline Messier, Daniel Grenier
Feb 22, 2012·Amino Acids·Luís S Monteiro, Ana S Suárez
Mar 1, 2012·Critical Reviews in Food Science and Nutrition·Chrystalleni LazarouAntonia-Leda Matalas
Citations
Nov 10, 2013·Journal of Ethnopharmacology·Xiaoying WangXiumei Gao
Feb 20, 2014·Journal of Natural Medicines·Chin Piow WongHiroshi Morita
Jan 8, 2016·Obesity Research & Clinical Practice·Meriga BalajiSreenivasulu Dasari
Apr 18, 2017·Journal of Oleo Science·Koki Takahashi, Kyoichi Osada
Dec 17, 2014·European Journal of Nutrition·Bo ZouChunmei Li
May 1, 2019·Medicinal Chemistry·Ioannis Fotopoulos, Dimitra Hadjipavlou-Litina
Jun 9, 2017·FEBS Open Bio·Kenta KuramotoMasashi Okada
Jul 12, 2019·World Journal of Stem Cells·Hui Li, Bing Yue
Jan 30, 2013·Biological & Pharmaceutical Bulletin·Masataka TajimaKiyoshi Sugiyama
Jan 4, 2017·PPAR Research·Soonkyu ChungMyoungsook Lee
May 15, 2019·Cells·Chian-Jiun LiouWen-Chung Huang
Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Danni WangXin Chai
Feb 20, 2021·Journal of Agricultural and Food Chemistry·Zhonghua LuoYuqing Zhao
Aug 11, 2018·Biochemical and Biophysical Research Communications·Hye Eun LeeJoo Young Lee
May 17, 2021·European Journal of Medicinal Chemistry·Carlos Villarroel-VicenteNuria Cabedo
Jul 18, 2021·Journal of Ethnopharmacology·Anuj Kumar BorahJagat Chandra Borah
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fen YangLiang Liu