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Lidocaine as treatment for neonatal seizures: evaluation of previously developed population pharmacokinetic models and dosing regimen

British Journal of Clinical Pharmacology

Oct 30, 2019

Laurent M A FaviePharmaCool study group

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Abstract

Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants. It is effective, but also associated with cardiac toxicity. Previous studies have reported on the pharmacokinetics of lidocaine in preterm and term neonates and proposed a dosing regimen for effective and ...read more

Mentioned in this Paper

Anticonvulsants
Hypothermia, Induced
Lidocaine
Drug Kinetics
Plasma
Treatment Protocols
Pharmacokinetic Study
Evaluation
Simulation
Cardiotoxicity
1
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Lidocaine as treatment for neonatal seizures: evaluation of previously developed population pharmacokinetic models and dosing regimen

British Journal of Clinical Pharmacology

Oct 30, 2019

Laurent M A FaviePharmaCool study group

PMID: 31663153

DOI: 10.1111/bcp.14136

Abstract

Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants. It is effective, but also associated with cardiac toxicity. Previous studies have reported on the pharmacokinetics of lidocaine in preterm and term neonates and proposed a dosing regimen for effective and ...read more

Mentioned in this Paper

Anticonvulsants
Hypothermia, Induced
Lidocaine
Drug Kinetics
Plasma
1

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