Lidocaine attenuates the hypotensive and inflammatory responses to endotoxemia in rabbits

Critical Care Medicine
T TaniguchiY Nakanuma

Abstract

To assess the effects of lidocaine on the hemodynamic and inflammatory responses to Escherichia coli endotoxemia in rabbits. Prospective, randomized, controlled experimental study. University laboratory. Twenty-seven female Japanese rabbits, anesthetized with urethane and ventilated mechanically. Animals were randomly assigned to one of three groups: a) endotoxemic control group (n = 9), receiving intravenous Escherichia coli endotoxin (0.5 mg/kg bolus) via the mesenteric vein; b) laparotomy control group (n = 9), treated identically to the endotoxemic control group, except for substitution of 0.9% saline for endotoxin; and c) lidocaine-treated group (n = 9), treated identically to the endotoxemic controls and additionally, intravenous lidocaine (3 mg/kg bolus, followed by infusion at 2 mg/kg/hr) was administered immediately after endotoxin We compared hemodynamics, blood gases, and microscopic findings of lung tissue obtained at necropsy in each group. Laparotomy alone had a minimal effect on the parameters and findings. Endotoxin injection decreased mean systolic arterial pressure from 135 +/- 6 (SD) to 95 +/- 25 mm Hg (p < .05) and increased the mean base deficit from -1.2 +/- 1.8 to -14.4 +/- 4.2 mmol/L (p < .05), and cause...Continue Reading

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Citations

Jul 24, 2010·Journal of Veterinary Internal Medicine·J R PeiróC A A Valadão
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Thomas J Doherty, M Reza Seddighi
Aug 12, 2010·The Veterinary Clinics of North America. Equine Practice·Bernd DriessenLaura Zarucco
Dec 9, 2008·Journal of Dentistry·Hugo Cesar Pinto Marques CaracasLucianne Cople Maia
May 1, 2016·The Veterinary Clinics of North America. Exotic Animal Practice·Minh HuynhCharly Pignon
Dec 12, 2001·European Journal of Anaesthesiology·B Gunaydin, A T Demiryurek
Jan 25, 2003·International Anesthesiology Clinics·Brian J Swanton, George D Shorten

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