PMID: 3757781Sep 1, 1986Paper

Lidocaine excretion in breast milk

Drug Intelligence & Clinical Pharmacy
J A ZeislerS A De Mesquita

Abstract

Nursing mothers are occasionally treated with intravenous lidocaine for ventricular dysrhythmias. There have been no reports on the excretion of lidocaine into breast milk. This case documents the excretion of lidocaine into breast milk in small amounts and shows the validity of the TDx methodology used in the whole-milk lidocaine assay. We observed breast-milk concentrations of lidocaine at 40 percent of the serum levels. Clinical practitioners should be aware the lidocaine is excreted into breast milk in small amounts and the mother could probably continue to safely breast-feed her child while on parenteral lidocaine. Any adverse reactions in the nursing infant would probably be limited to an idiosyncratic or allergic reaction.

References

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Citations

Jun 6, 2000·Plastic and Reconstructive Surgery·R M Dryden, M W Lo
Apr 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·M GiulianiG Casparrini
Apr 17, 2013·Current Opinion in Anaesthesiology·Aidan SharkeyJohn G McDonnell
Jul 1, 1993·Anaesthesia·J J Lee, A P Rubin
Nov 14, 1997·Anesthesia and Analgesia·J P RathmellM A Ashburn
Jan 25, 2013·AJR. American Journal of Roentgenology·Reena VashiLiane Philpotts
Feb 1, 1994·Acta Anaesthesiologica Scandinavica·O Spigset
Dec 1, 1999·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·T W Hale
Sep 17, 2009·Journal of Veterinary Pharmacology and Therapeutics·G SellersM D Givens
Jan 17, 2021·American Journal of Obstetrics & Gynecology MFM·Kathleen M AntonyAmye J Tevaarwerk

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