Lidocaine impairs vasodilation mediated by adenosine triphosphate-sensitive K+ channels but not by inward rectifier K+ channels in rat cerebral microvessels.

Anesthesia and Analgesia
H KinoshitaYoshio Hatano

Abstract

Vasodilator effects of adenosine triphosphate (ATP)-sensitive, as well as inward rectifier, K+ channel openers have not been well demonstrated in cerebral microvessels. Although lidocaine impairs vasorelaxation via ATP-sensitive K+ channels in the rat aorta, the effects of this compound on K+ channels in the cerebral circulation have not been shown. We designed the present study to examine whether ATP-sensitive and inward rectifier K+ channels contribute to vasodilator responses in cerebral microvessels and whether the vasodilation mediated by these channels is inhibited by lidocaine. Rat brain slices were monitored using a computer-assisted videomicroscopy. Cerebral parenchymal arterioles (diameter, 5-10 microm) were contracted with prostaglandin F(2alpha), and thereafter potassium chloride (KCl), levcromakalim, or sodium nitroprusside was added to the perfusion chamber. Levcromakalim and KCl produced vasodilation of the cerebral parenchymal arterioles, which was abolished by an ATP-sensitive K+ channel antagonist, glibenclamide, or an inward rectifier K+ channel antagonist, barium chloride, respectively. Lidocaine (10(-5) to 3 x 10(-5) M) inhibited the dilation produced by levcromakalim but not by KCl or sodium nitroprusside....Continue Reading

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Citations

Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Daisy T Joo, Gail K Wong
Jan 24, 2009·Stroke; a Journal of Cerebral Circulation·Joseph P MathewUNKNOWN Neurologic Outcome Research Group (NORG) of the Duke Heart Center
Mar 18, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kathryn M Dunn, Mark T Nelson
Sep 17, 2016·Canadian Journal of Physiology and Pharmacology·Jiseok BaikJu-Tae Sohn
Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano

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