PMID: 8945744Nov 1, 1996Paper

Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats

Neuroscience Letters
A PertovaaraM M Hämäläinen

Abstract

In the present study we attempted to find out if the rostroventromedial medulla (RVM) or the periaqueductal gray (PAG) might contribute to chronic allodynia induced by unilateral ligation of two spinal nerves in the rat. Lidocaine was microinjected in the RVM or PAG and allodynia was quantitatively determined by measuring the hindlimb withdrawal thresholds to mechanical stimulation of the paw. For comparison, lidocaine was also injected systemically (s.c.). Lidocaine in the RVM produced a dose-related (20 and 40 micrograms) antiallodynic effect. Lidocaine (20 micrograms) in the PAG produced identical antiallodynic effect as in the RVM. With systemic administrations of lidocaine, a considerably higher dose (> > 40 micrograms) was needed to produce a significant antiallodynic effect. Naloxone, an opioid-antagonist (1 mg/kg s.c.), did not attenuate the antiallodynic effect of lidocaine in the RVM. An antiallodynic dose of lidocaine (20 micrograms) in the RVM or the PAG did not influence the withdrawal response in the unoperated hindlimb nor the heat-induced tail-flick reflex. The results indicate that the RVM and the PAG have a facilitatory influence on the spinal segmental mechanisms underlying chronic allodynia. The selective at...Continue Reading

References

Apr 1, 1992·Pain·John E McKenna, Ronald Melzack
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 1, 1982·British Journal of Anaesthesia·R A BoasA Shahnarian

❮ Previous
Next ❯

Citations

Mar 17, 2001·Current Pain and Headache Reports·B K Taylor
Jan 8, 2009·Current Pain and Headache Reports·Charlie K WangIan Carroll
Jun 28, 2002·Trends in Neurosciences·Frank PorrecaG F Gebhart
Aug 26, 2003·Advanced Drug Delivery Reviews·Janean E Holden, Julie A Pizzi
Mar 20, 2002·Progress in Neurobiology·Deolinda Lima, Armando Almeida
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M O Urban, G F Gebhart
Apr 12, 2003·Brain : a Journal of Neurology·Didier BouhassiraNadine Atta
Oct 28, 2011·Journal of Neurophysiology·Thaddeus S BrinkDonald A Simone
Nov 3, 2010·The Journal of Clinical Investigation·Michael H OssipovFrank Porreca
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mai Lan LeongMartin Wessendorf
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming GuFeng Wei
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng WeiRonald Dubner
Feb 4, 2014·International Journal of Clinical Rheumatology·Roland Staud
Mar 10, 2010·Brain Research·Ahmad Mohammadi-FaraniMahmoud Ghazi-Khansari
Jul 17, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Graham M PitcherJames L Henry
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·A KvarnströmT Gordh
Jul 23, 2013·The European Journal of Neuroscience·Mónica Ambriz-TututiAnd René Drucker-Colín
Mar 18, 2016·Pain Management·Milena De Felice, Michael H Ossipov
Dec 2, 2004·Brain Research. Brain Research Reviews·Horacio Vanegas, Hans-Georg Schaible
Apr 25, 2006·The Journal of Pain : Official Journal of the American Pain Society·Ron AmirGary R Strichartz
Mar 21, 2006·European Journal of Pharmacology·Hong Wei, Antti Pertovaara
Nov 4, 2005·Experimental Neurology·Charles H Hubscher, Richard D Johnson
Jul 19, 2002·Rheumatic Diseases Clinics of North America·Srinivas G Rao
Jan 27, 2015·Drug Development Research·Jorge B Pineda-FariasVinicio Granados-Soto
Mar 16, 2012·Brain Research·Alianda Maira CornélioMichael M Morgan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.