PMID: 15220779Jun 29, 2004Paper

Lidocaine increases intracellular sodium concentration through voltage-dependent sodium channels in an identified lymnaea neuron

Anesthesiology
Shin OnizukaMayumi Takasaki

Abstract

The local anesthetic lidocaine affects neuronal excitability in the central nervous system; however, the mechanisms of such action remain unclear. The intracellular sodium concentration ([Na]i) and sodium currents (INa) are related to membrane potential and excitability. Using an identifiable respiratory pacemaker neuron from Lymnaea stagnalis, the authors sought to determine whether lidocaine changes [Na]i and membrane potential and whether INa is related to these changes. Intracellular recording and sodium imaging were used simultaneously to measure membrane potentials and [Na]i, respectively. Measurements for [Na]i were made in normal, high-Na, and Na-free salines, with membrane hyperpolarization, and with tetrodotoxin pretreatment trials. Furthermore, changes of INa were measured by whole cell patch clamp configuration. Lidocaine increased [Na]i in a dose-dependent manner concurrent with a depolarization of the membrane potential. In the presence of high-Na saline, [Na]i increased and the membrane potential was depolarized; the addition of lidocaine further increased [Na]i, and the membrane potential was further depolarized. In Na-free saline or in the presence of tetrodotoxin, lidocaine did not change [Na]i. Similarly, hyp...Continue Reading

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Citations

Sep 23, 2008·Anesthesia and Analgesia·Shin OnizukaMayumi Takasaki
Jan 9, 2015·Scientific Reports·Xing-Xing WuJianwei Shuai
Feb 8, 2018·Frontiers in Physiology·Ryden ArmstrongNaweed Syed
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Hannah TettehSungchil Yang
Oct 16, 2018·Lasers in Surgery and Medicine·Adam B RaffMartin Purschke
Aug 12, 2005·Journal of Neurophysiology·Manabu SakakibaraKen Lukowiak
Aug 30, 2008·Environmental Science & Technology·Lina GunnarssonD G Joakim Larsson

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