Lidocaine inhibits blood coagulation: implications for epidural blood patch

Anesthesia and Analgesia
M D TobiasD R Jobes

Abstract

Lidocaine in the epidural space, through inhibitory effects upon coagulation, may contribute to inefficacy of epidural autologous blood patch (EBP). This study was undertaken to evaluate the effect of achievable epidural concentrations of lidocaine on blood coagulation as a step in testing this hypothesis. Ex vivo blood coagulation using whole blood (n = 20) was studied with computerized thrombelastography (TEG). Each blood specimen was exposed to serial dilutions of lidocaine hydrochloride or saline to form end-concentrations of 0.0 mM, 2.3 mM, 4.6 mM, 9.2 mM, 18.5 mM, and 36.9 mM lidocaine. Statistical analysis using analysis of variance for repeated measures revealed that the three highest lidocaine concentrations tested caused hypocoagulable and/or fibrinolytic changes as compared with controls. Achievable epidural admixtures of lidocaine and whole blood will impair coagulation. Therefore, residual lidocaine in the epidural space may contribute to failures of immediate or early EBP.

References

Sep 1, 1992·British Journal of Anaesthesia·S V Mallett, D J Cox
Oct 1, 1992·British Journal of Anaesthesia·M D Seeberger, A Urwyler
Sep 1, 1987·Anesthesia and Analgesia·K J TumanA D Ivankovich
May 1, 1985·Anesthesia and Analgesia·P H Rosenberg, J E Heavner
Sep 1, 1974·Anesthesia and Analgesia·W S HowlandP Gould
Dec 1, 1984·Anesthesia and Analgesia·R F Cucchiara, D J Wedel
Oct 1, 1993·Acta Anaesthesiologica Scandinavica·T TaivainenP H Rosenberg

❮ Previous
Next ❯

Citations

Sep 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P J Duffy, E T Crosby
Apr 9, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pamela AngleJohn Paul Szalai
Apr 20, 2001·Current Pain and Headache Reports·G M Vasdev, P A Southern
Jan 4, 2001·Journal of Clinical Anesthesia·J H WatersJ A Grass
Jul 9, 1999·Journal of Clinical Anesthesia·M D TobiasY G Augostides
Aug 24, 2004·International Journal of Obstetric Anesthesia·H Gorton, G Lyons
Oct 8, 2003·Best Practice & Research. Clinical Anaesthesiology·Kenneth D Candido, Rom A Stevens
May 1, 1998·Acta Anaesthesiologica Scandinavica·N Dahlgren
Aug 26, 2014·Seminars in Perinatology·Adam Sachs, Richard Smiley
Apr 22, 2014·Journal of Anesthesia·Bhavani Shankar KodaliRichard D Urman
Oct 3, 2012·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Jiin-Tarng LiouYuan-Ji Day
Aug 21, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·M A HachimiA Mahmoudi
Sep 24, 2004·Anesthesia and Analgesia·Lewis S Coleman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.