Lidocaine plasma concentrations in pediatric patients after providing airway topical anesthesia from a calibrated device

Anesthesia and Analgesia
P SitbonC Mercier

Abstract

The aim of this prospective study was to evaluate plasma lidocaine concentrations in infants and children after laryngeal spray using a calibrated device. Twenty-one patients aged 3 to 24 mo requiring laryngoscopy or bronchoscopy were included in the study. Anesthesia was induced via a mask with halothane up to 2% in 100% O2. Lidocaine was administered using a 5% lidocaine spray. For patients weighing less than 10 kg, one spray (8 mg of lidocaine) was administered. For those weighing from 10 to 20 kg, two sprays (16 mg) were given. The dose of lidocaine administered ranged between 0.9 and 2.6 mg/kg. Maximum plasma lidocaine concentration (Cmax) was 1.05 +/- 0.55 micrograms/mL (mean +/- SD; range 0.24-2.29 micrograms/mL). With this procedure, we demonstrated the safety of administering lidocaine to children by laryngeal spraying using a 5% sprayer.

References

Aug 1, 1978·Anaesthesia and Intensive Care·R L EyresT C Brown
Sep 1, 1976·British Journal of Anaesthesia·D B ScottG B Drummond
May 1, 1970·Canadian Anaesthetists' Society Journal·D A PeltonA W Conn
Feb 1, 1983·Anaesthesia and Intensive Care·R L EyresT C Brown
Apr 2, 1960·Journal of the American Medical Association·F F FOLDESL R KOUKAL

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Citations

Mar 15, 2005·Der Anaesthesist·Andreas Machotta
Jan 12, 2000·Pediatric Clinics of North America·J D McAllister, K A Gnauck
Feb 19, 2002·Paediatric Anaesthesia·Lionel SimonAnne-Marie Dubousset
Jan 13, 2004·Clinical Pharmacokinetics·Jean-Xavier Mazoit, Bernard J Dalens
Nov 20, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·A LamblinM Puidupin
Feb 28, 2016·Paediatric Anaesthesia·Mari H Roberts, Christopher D Gildersleve
Sep 20, 2011·Paediatric Anaesthesia·Jean-Xavier Mazoit

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