Abstract
Periodontal inflammation causes endothelial dysfunction of the systemic artery. However, it is unknown whether the use of local anesthetics during painful dental procedures alleviates periodontal inflammation and systemic endothelial function. This study was designed to examine whether the gingival or systemic injection of lidocaine prevents oxidative stress-induced endothelial dysfunction of the systemic artery in rats with intermittent periodontal inflammation caused by lipopolysaccharides (LPS). Some rats received 1500 µg LPS injections to the gingiva during a week interval from the age of 8 to 11 weeks (LPS group). Lidocaine (3 mg/kg), LPS + lidocaine (3 mg/kg), LPS + lidocaine (1.5 mg/kg), and LPS + lidocaine (3 mg/kg, IP) groups simultaneously received gingival 1.5 or 3 mg/kg or IP 3 mg/kg injection of lidocaine on the same schedule as the gingival LPS. Isolated aortas or mandibles were subjected to the evaluation of histopathologic change, isometric force recording, reactive oxygen species, and Western immunoblotting. Mean blood pressure and heart rate did not differ among the control, LPS, LPS + lidocaine (3 mg/kg), and lidocaine (3 mg/kg) groups. LPS application reduced acetylcholine (ACh, 10 to 10 mol/L)-induced relax...Continue Reading
References
Feb 1, 1990·British Journal of Pharmacology·P K MooreA Gibson
Feb 7, 2001·Critical Care Medicine·T TaniguchiT Kobayashi
Dec 1, 2001·Anesthesia and Analgesia·K ArakawaS Ogawa
May 24, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Salomon AmarJoseph A Vita
Jan 10, 2006·Periodontology 2000·Janet H SoutherlandSteven Offenbacher
May 26, 2006·Journal of Dental Research·R LiuD T Graves
Sep 12, 2006·Atherosclerosis·Josefin PaulssonJoachim Lundahl
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Mar 3, 2007·The New England Journal of Medicine·Maurizio S TonettiJohn Deanfield
Sep 14, 2007·Journal of Clinical Periodontology·Jill L StoltenbergBryan S Michalowicz
Jul 7, 2011·Hypertension·Heinrich E LobDavid G Harrison
Mar 14, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jun-Hua FanNaohisa Ishikawa
Mar 24, 2012·Atherosclerosis·Janet H SoutherlandSteven Offenbacher
May 16, 2012·Journal of Periodontal Research·Y YoshinagaY Hara
Nov 14, 2012·Free Radical Biology & Medicine·Adem KaraSinan Tozoglu
Aug 6, 2013·Journal of Clinical Periodontology·Tatiana M P PintoCarlos H Moreira
Oct 3, 2013·Journal of Cardiovascular Pharmacology·Andreas JekellThomas Kahan
Dec 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian BergerAlexander Zarbock
Mar 19, 2014·Journal of Clinical Periodontology·Sonja H M DermanMichael J Noack
Jun 13, 2014·Circulation Research·Julie K FreedDavid D Gutterman
Aug 6, 2015·Basic Research in Cardiology·S WagnerO Friedrich
Nov 26, 2015·PloS One·Julio R ChavezSergio Recillas-Morales
Dec 23, 2015·Archives of Oral Biology·Paula CampiMarcelo Nicolas Muscara
Jul 16, 2016·Pflügers Archiv : European journal of physiology·Noboru Toda, Tomio Okamura
Aug 16, 2016·International Journal of Cardiology·Yasuhiro YamamotoHiroyuki Kinoshita
Citations
Jan 10, 2018·Frontiers in Physiology·L'ubomíra Tóthová, Peter Celec
Feb 20, 2019·Inflammation·Anna ScanuLeonardo Punzi
Feb 23, 2020·British Journal of Pharmacology·Mohamed A FoudaPeter C Ruben
Jul 29, 2019·Inflammopharmacology·Yao-Yao BaiChi Xiao
Jul 25, 2019·International Journal of Molecular Sciences·Mineaki KitamuraHideki Sakai
Jun 25, 2020·BMC Anesthesiology·Marco PustettoLuc Van Obbergh
Nov 24, 2019·International Journal of Pharmaceutics·Sim Yee LimCharles M Heard