Lidocaine sprayed down the endotracheal tube attenuates the airway-circulatory reflexes by local anesthesia during emergence and extubation

Anesthesia and Analgesia
Daelim Jee, So Young Park

Abstract

To determine whether lidocaine sprayed down the endotracheal tube (ETT) would attenuate airway-circulatory reflexes during emergence, we compared the reflex responses after endotracheal or IV lidocaine (IVL) in 75 patients receiving a standardized anesthetic protocol. At the end of surgery, the patients were divided into 3 groups (n = 25 for each group) and given no drug (Group 1), given 1 mg/kg of 2% lidocaine sprayed down the ETT 5 min before (Group 2), or given the same dose of IVL 3 min before extubation (Group 3). Blood pressure and heart rate were recorded at predetermined time points from 5 min (baseline) before until 5 min after extubation. The number of coughs per patient was continuously monitored during this period. The number (mean +/- SD) of coughs was decreased in Group 2 (4.5 +/- 3.7) compared with the control (10.2 +/- 6.0) (P < 0.01) with no difference for the control versus Group 3 (7.8 +/- 4.6). The increase in blood pressure was only attenuated immediately before extubation (P < 0.05), whereas the increase in heart rate was attenuated (P < 0.05) at all (except baseline) time points (P < 0.05) in Group 2 compared with the control with no difference for the control versus Group 3. The results indicate that lid...Continue Reading

References

Sep 1, 1978·Canadian Anaesthetists' Society Journal·A V BidwaiV A Bidwai
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Citations

Apr 17, 2004·Der Anaesthesist·S PecherM W Hollmann
Feb 28, 2016·Paediatric Anaesthesia·Mari H Roberts, Christopher D Gildersleve
Oct 26, 2010·ANZ Journal of Surgery·Pankaj KundraSudeep Krishnappa
Sep 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Ramandeep KaurJie Li
Jul 20, 2007·Anaesthesia·A M MachataC K Spiss

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