Abstract
The movement of ions, particularly Ca2+, across the plasma membrane of neurons is regarded as an initial element of the development of ischemic neuronal damage. Because the mechanism by which lidocaine protects neurons against ischemia is unclear, the effects of lidocaine on the ischemia-induced membrane depolarization, histologic outcome, and the change in the intracellular Ca2+ concentration in the gerbil hippocampus were studied. The changes in the direct-current potential shift in the hippocampal CA1 area produced by transient forebrain ischemia for 4 min were compared in animals given lidocaine (0.8 micromol administered intracerebroventricularly) 10 min before ischemia and those given saline. The histologic outcome was evaluated 7 days after ischemia by assessing delayed neuronal death in hippocampal CA1 pyramidal cells in these animals. In a second study, hypoxia-induced intracellular Ca2+ increases were evaluated by in vitro microfluorometry in gerbil hippocampal slices, and the effects of lidocaine (10, 50, and 100 microM) on the Ca2+ accumulation were examined. In addition, the effect of lidocaine (100 microM) drug perfusion with a Ca2+-free ischemia-like medium was investigated. The preischemic administration of lido...Continue Reading
References
Jan 1, 1992·Neuroscience·V Henzi, A B MacDermott
Oct 14, 1991·Neuroscience Letters·A MitaniK Kataoka
Jul 1, 1991·Journal of Neurochemistry·N AdachiK Saeki
Feb 22, 1991·Brain Research·R A PaduaJ D Geiger
Jan 1, 1990·Annual Review of Cell Biology·R W Tsien, R Y Tsien
Jan 1, 1989·Life Sciences·L A Phebus, J A Clemens
Aug 28, 1989·Brain Research·S OzawaY Kudo
Apr 1, 1988·Journal of Neurochemistry·J Sánchez-Prieto, P González
Jan 1, 1985·Physiological Reviews·A J Hansen
Jan 1, 1966·Annual Review of Pharmacology·J M Ritchie, P Greengard
Nov 1, 1984·Journal of Neurochemistry·H BenvenisteN H Diemer
Nov 1, 1982·Acta Neurologica Scandinavica·M B Jørgensen, N H Diemer
Jul 1, 1980·Stroke; a Journal of Cerebral Circulation·M D GinsbergW W Budd
Jun 1, 1995·Journal of Neuroscience Methods·C P TaylorM L Weber
Sep 26, 1994·Neuroscience Letters·T FujitaniT Arai
Nov 21, 1994·Brain Research·M L Weber, C P Taylor
Aug 1, 1994·Brain Research·Y XieF Tegtmeier
Dec 1, 1994·Journal of Neurochemistry·A MitaniK Kataoka
Dec 1, 1994·Stroke; a Journal of Cerebral Circulation·P G LyskoG Feuerstein
Feb 1, 1994·Journal of Neurochemistry·A MitaniK Kataoka
Aug 9, 1993·FEBS Letters·C MartinV Shoshan-Barmatz
Jan 22, 1993·Brain Research·A MitaniK Kataoka
Dec 1, 1995·The Journal of Physiology·E FriedI S Kass
Citations
Jul 22, 1999·European Journal of Pharmacology·N AdachiT Arai
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·N BiaryM Tariq
Mar 20, 2002·Neuroscience Research·Shuhei NiiyamaHideho Higashi
Apr 18, 2002·Neuroscience Letters·Nobutaka KawaharaTakaaki Kirino
Oct 6, 1998·Neuroscience·J ChenT Arai
Mar 2, 1999·Neuroscience·T NakamuraY Kudo
Feb 3, 2005·Pharmacology·Laurent LecanuVassilios Papadopoulos
Jan 28, 2005·Anesthesia and Analgesia·Wei LanPaul H Redmond
Sep 30, 2005·Anesthesia and Analgesia·Hong CaoPeter J Bergold
Jan 17, 2013·Neuroscience·H NaitoK Morita
Apr 25, 2009·Acta Anaesthesiologica Scandinavica·T GoyagiY Masaki
Oct 7, 2004·Neuroscience·M Martínez-SánchezG Reiser
Apr 22, 2004·Neuroscience·B LeiI S Kass
Sep 27, 2005·Brain Research. Brain Research Reviews·Naoto Adachi
Jul 5, 2005·Neuropharmacology·Laurent LecanuVassilios Papadopoulos
Dec 3, 2002·Anesthesiology·Baiping LeiIra S Kass
Apr 21, 2005·Journal of Neurosurgical Anesthesiology·Frank-Joachim SeyfriedTatsuru Arai
Aug 17, 2001·Anesthesiology·B LeiI S Kass
Jun 30, 2006·American Journal of Physiology. Cell Physiology·Takashi KawasakiIrshad H Chaudry
Jul 25, 2000·Journal of Neurosurgical Anesthesiology·J LiM Hirakawa
Oct 4, 2006·Current Opinion in Anaesthesiology·S E Ricksten
Oct 5, 2006·Current Opinion in Anaesthesiology·P Hans, V Bonhomme
Dec 4, 2001·Journal of Neurophysiology·K M Raley-SusmanJ Wang
Sep 2, 2000·Anesthesiology·M W Hollmann, M E Durieux
Apr 27, 2021·European Journal of Pharmacology·King-Chuen WuYuk-Man Leung
Jun 24, 1998·Brain Research·J ChenT Arai
Jul 2, 2021·BioMed Research International·Andrea RomeraCarlos Simón