PMID: 9416732Jan 7, 1998Paper

Lidocaine suppresses the anoxic depolarization and reduces the increase in the intracellular Ca2+ concentration in gerbil hippocampal neurons

Anesthesiology
K LiuTatsuru Arai

Abstract

The movement of ions, particularly Ca2+, across the plasma membrane of neurons is regarded as an initial element of the development of ischemic neuronal damage. Because the mechanism by which lidocaine protects neurons against ischemia is unclear, the effects of lidocaine on the ischemia-induced membrane depolarization, histologic outcome, and the change in the intracellular Ca2+ concentration in the gerbil hippocampus were studied. The changes in the direct-current potential shift in the hippocampal CA1 area produced by transient forebrain ischemia for 4 min were compared in animals given lidocaine (0.8 micromol administered intracerebroventricularly) 10 min before ischemia and those given saline. The histologic outcome was evaluated 7 days after ischemia by assessing delayed neuronal death in hippocampal CA1 pyramidal cells in these animals. In a second study, hypoxia-induced intracellular Ca2+ increases were evaluated by in vitro microfluorometry in gerbil hippocampal slices, and the effects of lidocaine (10, 50, and 100 microM) on the Ca2+ accumulation were examined. In addition, the effect of lidocaine (100 microM) drug perfusion with a Ca2+-free ischemia-like medium was investigated. The preischemic administration of lido...Continue Reading

References

Jan 1, 1990·Annual Review of Cell Biology·R W Tsien, R Y Tsien
Jan 1, 1985·Physiological Reviews·A J Hansen
Jan 1, 1966·Annual Review of Pharmacology·J M Ritchie, P Greengard
Nov 1, 1982·Acta Neurologica Scandinavica·M B Jørgensen, N H Diemer

❮ Previous
Next ❯

Citations

Jul 22, 1999·European Journal of Pharmacology·N AdachiT Arai
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·N BiaryM Tariq
Sep 27, 2005·Brain Research. Brain Research Reviews·Naoto Adachi
Apr 21, 2005·Journal of Neurosurgical Anesthesiology·Frank-Joachim SeyfriedTatsuru Arai
Jun 30, 2006·American Journal of Physiology. Cell Physiology·Takashi KawasakiIrshad H Chaudry
Oct 4, 2006·Current Opinion in Anaesthesiology·S E Ricksten
Oct 5, 2006·Current Opinion in Anaesthesiology·P Hans, V Bonhomme
Dec 4, 2001·Journal of Neurophysiology·K M Raley-SusmanJ Wang
Sep 2, 2000·Anesthesiology·M W Hollmann, M E Durieux
Apr 27, 2021·European Journal of Pharmacology·King-Chuen WuYuk-Man Leung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.