PMID: 9554736Apr 29, 1998Paper

Lidocaine's effect on defibrillation threshold are dependent on the defibrillation electrode system: epicardial versus endocardial

Journal of Cardiovascular Electrophysiology
A P Winecoff MillerM R Ujhelyi

Abstract

Epicardial and endocardial defibrillation electrode systems affect myocardial electrophysiology and sympathetic function differently. Thus, we postulate that antiarrhythmic drugs will interact with these electrode systems differently. Defibrillation energy requirements (DER) at 20% (ED20), 50% (ED50), and 80% (ED80) success were measured at baseline and during lidocaine (10 mg/kg per hour) or D5W treatment for epicardial and endocardial electrodes. Pigs were randomized to treatment (lidocaine or D5W) and electrode system, which resulted in four experimental groups: (1) epicardial electrode + D5W; (2) epicardial electrode + lidocaine; (3) endocardial electrode + D5W; and (4) endocardial electrode + lidocaine. ED50 DER (mean +/- SEM) values at baseline for groups 1-4 were 10.6+/-1, 8.5+/-1, 12.6+/-1, and 12.3+/-1 J, respectively. DER values for groups 1 and 3 during D5W were similar to baseline. Conversely, lidocaine increased ED50 DER values from 8.5+/-1 to 13.5+/-2 J (P < 0.05) in group 2 animals (epicardial electrodes). When lidocaine was administered to group 4 animals (endocardial electrodes), however, ED50 DER values remained similar to baseline values (12.3+/-1 to 14.3+/-2 J, P = NS). Lidocaine increased ED50 DER values by...Continue Reading

References

May 1, 1989·Journal of the American College of Cardiology·R A WinkleT Shipman
Mar 1, 1989·The Journal of Clinical Investigation·D W FrazierR E Ideker
Feb 1, 1993·Pacing and Clinical Electrophysiology : PACE·D L WareD S Echt
Feb 1, 1995·Pacing and Clinical Electrophysiology : PACE·D E KoppD J Wilber
Mar 1, 1995·Pacing and Clinical Electrophysiology : PACE·D J LangD L Derfus
Feb 1, 1993·The Journal of Clinical Investigation·H C LeeE F Shibata
May 1, 1996·Journal of Cardiovascular Electrophysiology·L B RigdenD P Zipes
Jul 1, 1997·Journal of Cardiovascular Electrophysiology·S E BrodeF E Marchlinski

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Citations

Mar 29, 2008·Drugs·Anna Legreid DoppJames E Tisdale
Jan 18, 2018·Expert Review of Cardiovascular Therapy·Federico GuerraAlessandro Capucci
Mar 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·J Jason SimsNicholas A Wiegert

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