LIF potentiates the NT-3-mediated survival of spiral ganglia neurones in vitro

Neuroreport
P L MarzellaT J Kilpatrick

Abstract

The survival of auditory neurones depends on the continued supply of trophic factors. Early postnatal spiral ganglion cells (SGC) in a dissociated cell culture were used as a model of auditory innervation to test the trophic factors leukaemia inhibitory factor (LIF) and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings suggest that LIF supports neuronal survival in a concentration-dependent manner. Moreover LIF potentiated NT-3-mediated spiral ganglion neuronal survival in a synergistic fashion.

References

May 1, 1991·Journal of Cellular Biochemistry·D J Hilton, N M Gough
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Citations

May 5, 1999·Journal of Anatomy·G Terenghi
Jun 8, 2000·Annals of the New York Academy of Sciences·R A AltschulerJ M Miller
Oct 26, 2012·Expert Opinion on Biological Therapy·Karina NeedhamBryony A Nayagam
May 3, 2011·Hearing Research·Bryony A NayagamDavid K Ryugo
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Nov 3, 2005·The European Journal of Neuroscience·Lisa N Gillespie, Robert K Shepherd
Sep 27, 2002·British Medical Bulletin·Yehoash Raphael
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Phillip L Marzella, Lisa N Gillespie
Jul 1, 1999·Journal of Neurochemistry·B J DowsingT J Kilpatrick

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