Life expectancy in people with newly diagnosed epilepsy

Brain : a Journal of Neurology
Athanasios GaitatzisJosemir W Sander

Abstract

Epilepsy carries a risk of premature mortality, but little is known about life expectancy in people with the condition. The UK National General Practice Study of Epilepsy is a prospective, population-based study of people with newly diagnosed epilepsy. A cohort of 564 patients with definite epilepsy has been followed for nearly 15 years and there have been 177 deaths. These data have been used to estimate life expectancy of people in this cohort by employing a parametric survival model based on the Weibull distribution. Life expectancy in people with epilepsy was estimated as a function of age at, and time from, diagnosis according to two broad aetiological groups. These estimates were then compared with life expectancy in people of the same age and sex in the general population. Reduction in life expectancy can be up to 2 years for people with a diagnosis of idiopathic/cryptogenic epilepsy, and the reduction can be up to 10 years in people with symptomatic epilepsy. Reductions in life expectancy are highest at the time of diagnosis and diminish with time. Our model provides broad estimates, but it appears that the higher mortality rates in people with newly diagnosed epilepsy translate into decreased life expectancy.

Citations

Mar 17, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A EdidinS M Kurtz
Feb 15, 2005·Lancet·Torbjörn Tomson, Lars Forsgren
Feb 1, 2011·Brain : a Journal of Neurology·Aidan NeliganJosemir W Sander
Dec 24, 2010·Epilepsia·Aidan NeliganJosemir W Sander
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·B MortonS Duncan
Nov 19, 2008·Journal of the American Veterinary Medical Association·Simone SchrieflAndrea Fischer
Sep 2, 2008·Neurosurgical Focus·Scellig S D Stone, James T Rutka
Jul 5, 2013·Brain : a Journal of Neurology·Jan NovySanjay M Sisodiya
Oct 1, 2013·Epilepsy & Behavior : E&B·Cássia Regina Vancini-CampanharoAécio Flávio Teixeira de Góis
Oct 18, 2013·British Medical Bulletin·David M G Goodridge, Simon D Shorvon
May 18, 2012·Applied Health Economics and Health Policy·Avram A EdidinSteven M Kurtz
Mar 27, 2013·The International Journal of Neuroscience·Hao LiuFa-Fa Tian
Nov 13, 2013·Expert Review of Neurotherapeutics·Ann JacobySteven Schachter
Sep 14, 2007·Expert Review of Medical Devices·Erlick A C PereiraTipu Z Aziz
Sep 19, 2007·Expert Opinion on Emerging Drugs·Patrick Kwan, Martin J Brodie
Jul 2, 2014·Epilepsy & Behavior : E&B·Kenneth D LaxerSelim R Benbadis
Feb 24, 2016·Epilepsy Research·Dulaney A WilsonAnbesaw W Selassie
Jul 26, 2013·Lancet·Josemir W Sander
Jul 9, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·M LeyR Rocamora
Dec 26, 2007·Epilepsy & Behavior : E&B·Ann Jacoby, Gus A Baker
Jul 31, 2013·Epilepsia·Anders Gaarsdal HolstJacob Tfelt-Hansen
Sep 23, 2014·Epilepsia·Kitti KaiboriboonSiran M Koroukian
Apr 18, 2015·Neurobiology of Stress·Céline M DubéTallie Z Baram
Nov 6, 2007·Seizure : the Journal of the British Epilepsy Association·Tomor HarnodTerry B J Kuo
Jul 16, 2008·Seizure : the Journal of the British Epilepsy Association·Tomor HarnodTerry B J Kuo
Oct 9, 2012·Epilepsy & Behavior : E&B·Mary Jane EnglandLarisa M Strawbridge
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Po-Ching ChuYu-Yin Chang
Sep 28, 2014·Lancet·Solomon L MoshéTorbjörn Tomson
May 18, 2016·Glia·Ukpong B EyoLong-Jun Wu
Sep 21, 2016·Seizure : the Journal of the British Epilepsy Association·M Sillanpää, D Schmidt
Nov 27, 2016·Epilepsia·David J ThurmanUNKNOWN Epidemiology Commission of the International League Against Epilepsy
Apr 15, 2017·Epilepsy & Behavior : E&B·Musa M WatilaJosemir W Sander
Jan 25, 2017·Current Opinion in Neurology·Fenella J Kirkham
Feb 1, 2018·Brain Sciences·Venkatraman Sadanand
Jan 25, 2018·Brain : a Journal of Neurology·Christopher D WhelanSanjay M Sisodiya
Feb 10, 2018·Expert Review of Neurotherapeutics·Lance WatkinsJosemir W Sander
Jul 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Georgette L SuidanDenisa D Wagner
Dec 3, 2017·Neurology·Freya DiederichChristian Brettschneider
Sep 30, 2017·Epilepsia·Claudia A GranbichlerEugen Trinka
Jun 27, 2017·Frontiers in Neurology·Mariana Bocca NejmFulvio Alexandre Scorza
Nov 29, 2016·Frontiers in Neuroscience·Dubravka Svob StracGiuseppe Di Giovanni
Jun 9, 2020·Brain Injury : [BI]·Hanna Siig HaustedLene Odgaard
Oct 13, 2020·Frontiers in Neurology·Jing LiWeihong Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.