Life history of cones in the rhodopsin-mutant P23H-3 rat: evidence of long-term survival

Investigative Ophthalmology & Visual Science
Vicki ChrysostomouKrisztina Valter

Abstract

To follow the status of cones over the life of the P23H-3 transgenic rat, while the rod population is depleted. P23H-3 heterozygous and Sprague-Dawley (SD) control rats were raised in dim, cyclic light from postnatal day (P)10 to P540. Retinas were examined for cone density, cone outer segment (OS) length, cone axon and soma morphology, and the amplitude of rod and cone components of the electroretinogram (ERG) were determined. In the P23H-3 retina, cone density followed a developmental pattern, increasing from P10 until P20, declining during early adult life (to P150), then steadying at levels found in the SD retina until P540. Cone OSs elongated to P30 and then slowly shortened during late adulthood; at P350 and P540, cone OSs were significantly shorter than in the background SD strain. Cone axons shortened slowly throughout adult life as the outer nuclear layer thinned. The rod a-wave declined steadily in the P23H-3 retina from P10, falling below amplitudes seen in the SD strain from early life. By contrast, the cone b-wave maintained amplitude at SD levels, until P380. Despite the ongoing loss of rod function and numbers, cone numbers in the P23H-3 retina were maintained at levels found in the SD rat to the oldest age exami...Continue Reading

Citations

Mar 11, 2011·Journal of Neurophysiology·Chris SekirnjakE J Chichilnisky
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carole J SaadeJames M Fadool
Dec 15, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Faran SabetiTed Maddess
Feb 15, 2014·Neurobiology of Aging·Vicki ChrysostomouJonathan G Crowston
Apr 29, 2020·Investigative Ophthalmology & Visual Science·Katharina G FooteJacque L Duncan
Mar 23, 2017·Frontiers in Neuroanatomy·Johnny Di PierdomenicoMaría P Villegas-Pérez

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