Life-long physical activity restores metabolic and cardiovascular function in type 2 diabetes

European Journal of Applied Physiology
Tim H A SchreuderMaria T E Hopman

Abstract

Short-to-moderate duration exercise training improves fitness and lowers cardiovascular risk in type 2 diabetes (T2DM). However, the impact of long-term compliance to an active lifestyle of T2DM patients on cardiovascular risk factors has never been studied but could provide information on the maximal achievable health effect of physical activity in T2DM. This study examined the impact of a life-long active lifestyle by comparing physical fitness, cardiovascular risk and vascular function between long-term physically active T2DM patients versus sedentary T2DM patients and controls. Fitness, HOMA-IR, brachial artery flow-mediated dilation (FMD) and lifetime risk for cardiovascular disease were assessed in 15 exercising T2DM patients, 12 age-, sex- and weight-matched sedentary T2DM patients and 9 sedentary men free of established cardiovascular and metabolic disease as controls. Long-term regular exercise was defined as self-reported participation of >2.5 h of (predominantly) endurance exercise per week, which was performed for 18-47 years. Sedentary T2DM patients showed lower fitness (21.8 ± 2.3, 32.6 ± 6.0 and 31.1 ± 3.2 ml O2/kg/min), higher HOMA-IR (8.3 ± 5.0, 2.0 ± 1.8 and 1.1 ± 0.5 100/%S) and higher lifetime risk scores (1...Continue Reading

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Citations

Dec 7, 2018·Expert Review of Endocrinology & Metabolism·Orsolya M PalaciosKevin C Maki
Mar 20, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jordan LoaderMatthieu Roustit
Sep 17, 2019·Journal of the American College of Nutrition·Orsolya M PalaciosIndika Edirisinghe
Sep 14, 2017·Current Diabetes Reports·Emily M Miele, Samuel A E Headley
Nov 15, 2017·Cardiovascular Endocrinology·William M SchultzLaurence S Sperling

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