Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress

Annals of the New York Academy of Sciences
Olga A TjurminaDennis L Murphy

Abstract

This study examined whether serotonin transporter (SERT) deficiency influences adrenal serotonin (5-HT), catecholamine and Angiotensin II (Ang II) systems, and the hormonal response to acute restraint stress. Control SERT mice (+/+) expressed high numbers of SERT binding sites in adrenal medulla. Fifteen minutes of restraint stress increased adrenal 5-HT, adrenomedullary tyrosine hydroxylase (TH) mRNA expression and plasma epinephrine (EPI), and norepinephrine levels without alterations in adrenal catecholamine content. In SERT+/+, these responses coincided with a significant increase in adrenomedullary Ang II AT(2) receptor expression. SERT-deficient mice did not express SERT binding sites; their adrenal 5-HT was significantly depleted and further reduced after stress. They had exaggerated stress-induced EPI release into plasma, the increase in TH transcription did not occur, adrenal catecholamine content was decreased compared with SERT+/+, and stress induced a reduction rather than increase in the number of adrenomedullary AT(2) receptors. SERT-/- mice also possessed decreased pituitary 5-HT. Their pituitary ACTH was reduced after stress, but stress-induced increases in plasma ACTH and corticosterone were not different from ...Continue Reading

References

May 1, 1992·Endocrine Reviews·J M Saavedra

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Citations

Jan 30, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M L O SheaE J Lenze
Jan 13, 2011·Psychopharmacology·Nicole R NugentLawrence H Price
Apr 29, 2008·Neuroscience and Biobehavioral Reviews·Andrew Holmes
Jun 27, 2006·Biological Psychiatry·Alex Dranovsky, René Hen
Aug 9, 2005·Molecular and Cellular Endocrinology·Stuart J WardenCharles H Turner
Jan 23, 2008·Nature Reviews. Neuroscience·Dennis L Murphy, Klaus-Peter Lesch

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