PMID: 9441015Jan 24, 1998Paper

Life prognosis and macrovascular complications 10 years after diagnosis of type 2 diabetes

Casopís lékar̆ů c̆eských
J VálekH Storková

Abstract

Diabetes mellitus which develops in middle age is a serious complication, although its impact is often underrated due to relatively few symptoms and independence on insulin. The authors decided therefore to evaluate in 132 men with recently detected type 2 diabetes serious complications, evaluate the prognostic power of indicators apparent at the time of development of diabetes on the general mortality and macrovascular complications which were manifested within 10 years after detection of diabetes. From a group of men, mean age 50.6 +/- 8.5 years, who were examined in 1985-1986 at the Clinic of Diabetology and Experimental Therapy, IKEM, during this period 20 died (15%). The total mortality correlated with systolic blood pressure (154 +/- 26.2 mm Hg vs 140.5 +/- 16.5 mm Hg, p < 0.05), blood sugar level (8.8 +/- 3.0 mmol/l vs 7.4 +/- 2.7 mmol/l, p < 0.05), alpha 2 globulin levels (6.4 +/- 1.2 vs 5.2 +/- 1.1 g/l, p < 0.01, family history of infarction (p < 0.01) and ischaemic changes on the ECG tracing (p < 0.05). In multiple logistic regression the role of systolic pressure, blood sugar level, family history of infarction and also HDL cholesterol in relation to the status after 10 years was confirmed (r = 0.5378). Clinically co...Continue Reading

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