Life-threatening adverse drug reaction to paclitaxel. Postmarketing surveillance.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
A Ruiz-CasadoJ Guerra

Abstract

The mechanism of action of hypersensitivity reactions from paclitaxel has not been fully understood. It has not even been defined if they are secondary to paclitaxel, its vehicle or the premedication. Postmarketing pharmacovigilance is predominantly based on spontaneous reporting. These reports albeit biased and incomplete serve to detect previously unrecognised adverse events. We report a life threatening adverse event related to paclitaxel without any evidence of histamine release. It consisted of a cardiac arrest probably secondary to bradiarrhythmia or branch block.

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Citations

Feb 3, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lincy S LalWilliam Dana
Sep 21, 2007·Journal of Interventional Cardiology·Nicholas G KounisTheoharis C Theoharides
Dec 29, 2016·The AAPS Journal·Kaitlyn V Ledwitch, Arthur G Roberts
Nov 21, 2012·PloS One·John ArcherMiguel E Quiñones-Mateu
Oct 17, 2014·AIDS Research and Human Retroviruses·Claudia MontagnaGuido Antonelli

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