Life-threatening hypercalcemia associated with primary hyperparathyroidism during pregnancy: case report and review of literature.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
N IqbalJ W Edmondson

Abstract

To report a case of life-threatening hypercalcemia attributable to primary hyperparathyroidism in a pregnant patient and discuss the management of severe hypercalcemia during pregnancy. We describe a 28-year-old pregnant woman who had life-threatening hypercalcemia (serum calcium level of 25.8 mg/dL). Primary hyperparathyroidism was diagnosed. The patient's management and the published medical literature on primary hyperparathyroidism during pregnancy are reviewed. Our patient had the highest reported serum calcium level that we could find attributable to primary hyperparathyroidism during pregnancy. After initial stabilization, parathyroidectomy was successfully performed during pregnancy. To our knowledge, this is the first report in which this profound degree of hypercalcemia did not result in an adverse maternal or fetal outcome. Although uncommon, primary hyperparathyroidism during pregnancy may be associated with severe maternal and perinatal complications. Life-threatening hypercalcemia due to primary hyperparathyroidism during pregnancy can be successfully managed surgically during pregnancy, with good maternal and fetal outcome.

References

Jun 1, 1976·Archives of Surgery·J J Livesay, D G Mulder
Apr 1, 1978·Archives of Disease in Childhood·B B JacobsenO H Sørensen
Mar 1, 1976·American Journal of Surgery·F L DelmonicoP S Russell
Jun 1, 1977·The Surgical Clinics of North America·J A van HeerdenL B Woolner
Mar 1, 1977·The British Journal of Surgery·T J CookeS Taylor
Jul 1, 1992·Journal of General Internal Medicine·M J Carella, V V Gossain
Jul 1, 1992·Annals of Clinical Biochemistry·H WilkinsonA Stott
Jul 1, 1989·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N C HillJ D Goodman
Nov 1, 1989·The British Journal of Surgery·J S GelisterE J Milroy
Feb 1, 1989·Journal of Endocrinological Investigation·J M Lopez, C B Fardella
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·O K DavisI Schiff
Apr 22, 1988·Deutsche medizinische Wochenschrift·G WarnekeF Scheler
Aug 1, 1987·British Journal of Obstetrics and Gynaecology·G S MatthiasA Williams
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·B Fabrin, K Eldon
Jan 1, 1985·American Journal of Obstetrics and Gynecology·R M Pitkin
Jan 1, 1970·Annals of Surgery·R C HaffW F Ballinger
Sep 1, 1970·The American Journal of the Medical Sciences·D BronskyJ J Barton
Feb 3, 1966·The New England Journal of Medicine·H Hartenstein, L I Gardner
Jun 1, 1966·Acta Endocrinologica·R E GoldsmithA S Weinstein
May 1, 1983·American Journal of Surgery·D K LoweC G Peterson
Nov 1, 1983·Southern Medical Journal·M C Lueg, W E Dawkins
Mar 1, 1984·The British Journal of Surgery·J NudelmannR Reiss
Apr 1, 1982·The Journal of Clinical Endocrinology and Metabolism·N A BreslauC Y Pak
May 1, 1982·The Australian & New Zealand Journal of Obstetrics & Gynaecology·C A Kirby, M D Read
Apr 1, 1982·Obstetrical & Gynecological Survey·M M ShangoldM C Crenshaw
Aug 1, 1981·American Journal of Obstetrics and Gynecology·D ClarkR C Cefalo
Jan 24, 1980·The New England Journal of Medicine·H HeathM A Kennedy
May 1, 1980·Postgraduate Medical Journal·A A DeutschR Reiss
Aug 1, 1993·Acta Obstetricia Et Gynecologica Scandinavica·P AmmannR Rizzoli
Jun 15, 1963·American Journal of Obstetrics and Gynecology·P J WHALLEY
Dec 1, 1964·Annals of Internal Medicine·P HUTCHIN, D M KESSNER
Sep 27, 1962·The New England Journal of Medicine·G D LUDWIG

❮ Previous
Next ❯

Citations

Apr 14, 2010·World Journal of Surgery·Todd P W McMullenLeigh W Delbridge
Sep 2, 2008·The Laryngoscope·Mai Thy TruongMichael Friduss
Jul 10, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·P Pothiwala, S N Levine
Apr 20, 2014·European Journal of Endocrinology·Ali Abood, Peter Vestergaard
Oct 19, 2012·The Angle Orthodontist·Boyen HuangKazuhisa Bessho
Mar 7, 2020·Journal of the Endocrine Society·Sonia G SharmaCherie Ann O Nathan

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Jessica L BrownMichael J Haller
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
F HarsoulisM Mamopoulos
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
M GidiriK Philips
Obstetrical & Gynecological Survey
Peter F Schnatz, Sara Thaxton
© 2022 Meta ULC. All rights reserved