Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study

The Lancet Child & Adolescent Health
Federico Martinón-TorresEUCLIDS Consortium

Abstract

Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe. The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures. 2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4-93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0-80·2), whereas those diagnosed with severe focal infections had a median age of ...Continue Reading

Citations

Aug 9, 2018·Archives of Disease in Childhood·David Philip InwaldUNKNOWN PERUKI (Paediatric Emergency Research in the UK and Ireland) and PICS SG (Paediatric Intensive Care Society Study Group)
Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
Jul 25, 2019·Current Opinion in Infectious Diseases·Luregn J Schlapbach
Apr 29, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Katie M MoynihanLuregn J Schlapbach
Nov 30, 2019·Scientific Reports·Xinzhu WangUNKNOWN EUCLIDS consortium
Feb 19, 2020·Human Genetics·Stephanie HodeibVanessa Sancho-Shimizu
May 28, 2019·MMW Fortschritte der Medizin·D Reinhardt
Jul 25, 2019·BMJ Paediatrics Open·Dorine BorensztajnHenriette A Moll
Oct 30, 2019·Open Forum Infectious Diseases·F SeckaS T Anderson
May 3, 2020·Clinical Chemistry·Sophie Trouillet-AssantUNKNOWN Antoine Study Group
Aug 7, 2020·Human Vaccines & Immunotherapeutics·Irene Rivero-CalleFederico Martinón-Torres
Aug 11, 2020·Frontiers in Pediatrics·Judith ZandstraUNKNOWN EUCLIDS Consortium, PERFORM Consortium and UK Kawasaki Disease Genetics Study Network
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bayarchimeg MashbatVanessa Sancho-Shimizu
Apr 25, 2020·International Journal of Molecular Sciences·Ruth Barral-ArcaAntonio Salas
Aug 11, 2020·The Pediatric Infectious Disease Journal·Joachim LuthanderAnna Nilsson
Jan 8, 2021·PloS One·Dorine M BorensztajnUNKNOWN PERFORM consortium: Personalised Risk assessment in febrile children to optimise Real-life Management across the European Un
Mar 13, 2021·The Pediatric Infectious Disease Journal·Antonio C ArrietaJohn S Bradley
Jun 4, 2021·Frontiers in Immunology·Judith ZandstraTaco W Kuijpers
Jun 3, 2021·International Journal of Molecular Sciences·Heather Jackson On Behalf Of The Perform Consortium
Aug 17, 2021·Frontiers in Pediatrics·Ruud G NijmanUNKNOWN PERFORM consortium (Personalized Risk assessment in febrile children to optimize Real-life Management across the European Un
Nov 30, 2019·Pediatrics·Heather E HsuChanu Rhee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

Revista Brasileira de terapia intensiva
Taís da Costa São PedroEmílio Carlos Elias Baracat
AIDS Research and Therapy
María Fernanda Álvarez BarrenecheCarlos Andrés Agudelo Restrepo
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
A G FaladeR A Adegbola
© 2022 Meta ULC. All rights reserved