Life-threatening QT prolongation in a boy with attention-deficit/hyperactivity disorder on atomoxetine

European Journal of Pediatrics
Hiroshi YamaguchiSatoru Kumaki

Abstract

As a noncentral nerve-stimulating agent blocking reuptake of noradrenalin, atomoxetine is used for treatment of attention-deficit/hyperactivity disorder (ADHD). Because it has less potential for addiction and abuse and improves core symptoms of ADHD, it is commonly prescribed in many children and adolescents internationally. Its common side effects include headache, abdominal pain, decreased appetite, and weight loss. In addition, cardiac effects such as tachycardia and hypertension have also been reported. In this case report, an 11-year-old Japanese boy with a past medical history of ADHD on atomoxetine for more than 2 years presented with a loss of consciousness. Initial electrocardiogram (ECG) showed significant QT prolongation, and 9 h later, it worsened, along with bradycardia, inversed T waves, and multiple premature ventricle contractions (PVCs). Transthoracic echocardiography showed akinesis with dilation and systolic ballooning of the left ventricle's (LV) apical segment (Takotsubo cardiomyopathy). At that point, bisoprolol and transcutaneous pacing were started. After 5 days, transcutaneous pacing was discontinued due to improvement in his cardiac rhythm. He continued to remain asymptomatic for the next year, while h...Continue Reading

References

Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Barbara J RingSteven A Wrighton
Apr 2, 2004·The American Journal of Psychiatry·Sharad Sawant, Steven R Daviss
Aug 23, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Daniel GellerCalvin Sumner
Feb 5, 2008·Pediatrics·Mark E BangsUNKNOWN Atomoxetine ADHD/ODD Study Group
Jan 22, 2009·British Journal of Pharmacology·Daniel SchererEberhard P Scholz
Dec 31, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Craig DonnellyThomas J Spencer
May 18, 2011·Pediatrics·Hedi SchellemanSean Hennessy
Nov 3, 2011·The New England Journal of Medicine·William O CooperWayne A Ray

❮ Previous
Next ❯

Citations

Jul 16, 2015·Cardiology in the Young·Tamika Rozema, Lisa R Klein
Jun 23, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Ibrahim Cansaran TanidirVolkan Tuzcu
Apr 29, 2016·Journal of Psychiatric Practice·Marcia L Verduin
Jan 9, 2020·European Heart Journal. Case Reports·Petros Athanassopoulos, Shams Y-Hassan
Apr 7, 2017·Therapeutic Advances in Drug Safety·Jose Martinez-RagaEloisa Carabal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
Musa CakıcıArif Su Ner
The Annals of Pharmacotherapy
Diane Nykamp, John Adam Titak
The Journal of Clinical Psychiatry
J F Wernicke, Christopher J Kratochvil
Journal of Insurance Medicine
D N Duddleston
© 2022 Meta ULC. All rights reserved