Lifelong exposure to dietary isoflavones reduces risk of obesity in ovariectomized Wistar rats

Molecular Nutrition & Food Research
Anne KurratPatrick Diel

Abstract

Traditional Asian diet rich in soy isoflavones (ISOs) is discussed to be linked to a lower obesity prevalence. In lifelong and short-term exposure scenarios we investigated effects of an ISO-rich diet on the body composition and development of obesity in female rats. Female Wistar rats grew up on ISO-free or ISO-rich control diet (CON ISO: 467 mg/kg diet). Starting postnatal day 83, ovariectomized and intact animals received high calorie Western diet (WD) in the absence or presence of ISO (WD ISO: 431 mg/kg diet) for 12 weeks to induce obesity or maintained on respective control diet (CON). One group starting ISO exposure after ovariectomy mimics short-term ISO exposure in postmenopausal Western women. Lifelong but not short-term ISO exposure resulted in reduced body weight, visceral fat mass, serum leptin, and smaller adipocytes. ISO decreased hepatic SREBP-1c, ACC, FAS, and PPARγ mRNA expression in nonobese animals. Moreover, ovariectomy reduced skeletal muscle weight, which was antagonized by both short-term and lifelong ISO exposure. Our results indicate that in female rats lifelong but not short-term ISO intake reduces the risk to develop obesity. Furthermore, lifelong and short-term ISO exposure may antagonize loss of ske...Continue Reading

References

Nov 2, 1995·Biochemical and Biophysical Research Communications·H MasuzakiK Nakao
Apr 1, 1997·Annals of Medicine·H Adlercreutz, W Mazur
Apr 15, 2000·Nature·M W SchwartzD G Baskin
May 8, 2002·The Journal of Clinical Investigation·Jay D HortonMichael S Brown
Jun 13, 2002·Environmental Health Perspectives·Daniel R Doerge, Daniel M Sheehan
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Molly C Carr
Jul 17, 2003·Endocrinology·Afia NaazPaul S Cooke
Aug 9, 2003·Nutrition Reviews·Isabelle DemontyPeter J H Jones
Jan 30, 2004·Recent Progress in Hormone Research·Kamal Rahmouni, William G Haynes
Jun 16, 2004·Molecular and Cellular Endocrinology·Sujong KimMi-Ock Lee
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Paul S Cooke, Afia Naaz
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Retha R NewboldWendy N Jefferson
Jun 23, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Tomasz SzkudelskiKatarzyna Szkudelska
Aug 20, 2005·Journal of Cellular Physiology·Cecilia Garofalo, Eva Surmacz
Jun 14, 2006·The British Journal of Nutrition·Branislav RadovićJosef Köhrle
Feb 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P Kopelman
Oct 17, 2007·Environmental Health Perspectives·Christopher R CederrothSerge Nef
Jun 7, 2008·Experimental Biology and Medicine·Anne Ørgaard, Lotte Jensen
May 13, 2009·Molecular and Cellular Endocrinology·Retha R NewboldWendy N Jefferson
Sep 24, 2009·Molecular Nutrition & Food Research·Alicja MortensenGerhard Sontag
Dec 22, 2009·Sports Medicine·Deborah L Enns, Peter M Tiidus
Mar 1, 2006·Journal of the American Statistical Association·Edsel A Peña, Elizabeth H Slate
Feb 5, 2011·Acta Pharmacologica Sinica·Sunhyo Jeong, Michung Yoon
Jan 18, 2012·Molecular and Cellular Endocrinology·Frederick S Vom SaalJulia A Taylor
Jan 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martina VeldersPatrick Diel
Jul 17, 2012·Advances in Nutrition·Rebecca Kanter, Benjamin Caballero
Dec 24, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rita S StrakovskyWilliam G Helferich
Mar 13, 2014·Menopause : the Journal of the North American Menopause Society·Marnie G SilversteinCarol A Shively
Apr 3, 2014·Physiological Reviews·Rashmi MullurGregory A Brent

❮ Previous
Next ❯

Citations

Dec 14, 2017·European Journal of Nutrition·Shinpei TabataKunihiro Sakuma
Mar 29, 2019·Environmental Health Perspectives·Julie M HallKenneth S Korach
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qihui LuoZhengli Chen
Sep 1, 2020·American Journal of Physiology. Endocrinology and Metabolism·Thaís Furtado CamargoMaria Esméria Corezola do Amaral
Sep 29, 2017·Journal of Clinical Biochemistry and Nutrition·Huanhuan LiuZhuoqin Jiang
Aug 25, 2017·Scientific Reports·Tzu-Wen L CrossVictoria J Vieira-Potter
Aug 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lin YinGuanhua Du

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.