PMID: 8952040Nov 1, 1996Paper

Lifespan and lesions in genetically heterogeneous (four-way cross) mice: a new model for aging research

Veterinary Pathology
Clarence ChrispRichard A Miller

Abstract

Genetically heterogeneous animal models provide many advantages for research on aging but have been used infrequently. We present here lifespan and lesion data from a study of mice bred as a cross between (AKR/J x DBA/2J)F1 females and (C57BL/6J x SJL/J)F1 males. In such a four-way cross population, each mouse is genetically unique, but replicate populations of essentially similar genetic structure can be generated quickly, at low cost, and of arbitrary size from commercially available, genetically stable hybrid parents. We employed a protocol in which mice judged to be severely ill were euthanatized to obtain tissue in optimal condition for necropsy, and we were able to infer a likely cause of illness in 42 of 44 animals. Malignant lymphoma, including at least four histopathologically distinct subtypes, was the most common cause and was also a frequent incidental finding in mice dying of other causes. Neoplastic disease, benign or malignant, was the sole or a contributing cause of illness in 90% of the mice for which a cause could plausibly be assigned. A wide range of lethal and nonlethal degenerative lesions was also noted. The coefficient of variation for lifespan in these genetically heterogeneous mice was 26%, similar to ...Continue Reading

References

Jan 1, 1977·Annual Review of Genetics·R Steeves, F Lilly
Sep 1, 1979·Journal of the National Cancer Institute·J M WardM S Linhart
Oct 1, 1976·Laboratory Animals·C RowlattM U Sheriff
May 1, 1991·Journal of Gerontology·R Weindruch, E J Masoro
Apr 1, 1988·Genetics·R GelmanE Yunis
May 1, 1973·Journal of the National Cancer Institute·G S SmithM R Mickey
Jul 1, 1966·Journal of Gerontology·J B Storer
Dec 1, 1984·Genetics·E J YunisM E Dorf
Jan 1, 1994·Advances in Cancer Research·M B Gardner

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Citations

Oct 28, 1999·Neurobiology of Aging·G E McClearn, S M Hofer
Sep 20, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R A MillerW Atchley
Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard A MillerDavid T Burke
Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anne U JacksonRichard A Miller
Nov 6, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruth LipmanRichard A Miller
Feb 9, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maggie VergaraRichard A Miller
Aug 12, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Huber R Warner
Apr 15, 2008·Cancer Detection and Prevention·Maricarmen D Planas-SilvaMichelle C Stone
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Suzanne K VolkmanSteven A Goldstein
Feb 18, 2015·Annual Review of Animal Biosciences·Sarah J MitchellRafael de Cabo
May 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kyle R TaylorCarlos E Rodriguez
Oct 16, 2015·Veterinary Pathology·E RadaelliF Marchesi
Jan 5, 2012·Veterinary Pathology·C F BraytonJ M Ward
Mar 1, 2018·Biochemistry. Biokhimii︠a︡·V N ManskikhA I Nikiforova
May 13, 2020·GeroScience·Dushani L PalliyaguruRafael de Cabo
Aug 19, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christin E BurdJames L Kirkland
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard A Miller, Clarence Chrisp

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