Lifespan of gamma/delta T cells.

The Journal of Experimental Medicine
D F Tough, J Sprent

Abstract

Information on the turnover and lifespan of murine gamma/delta cells was obtained by administering the DNA precursor, bromodeoxyuridine (BrdU), in the drinking water and staining lymphoid cells for BrdU incorporation. For TCR-gamma/delta (Vgamma2) transgenic mice, nearly all gamma/delta thymocytes became BrdU+ within 2 d and were released rapidly into the peripheral lymphoid tissues. These recent thymic emigrants (RTEs) underwent phenotypic maturation in the periphery for several days, but most of these cells died within 4 wk. In adult thymectomized (ATx) transgenic mice, only a small proportion of gamma/delta cells survived as long-lived cells; most of these cells had a slow turnover and retained a naive phenotype. As in transgenic mice, the majority of RTEs generated in normal mice (C57BL/6) appeared to have a restricted lifespan as naive cells. However, in marked contrast to TCR transgenic mice, most of the gamma/delta cells surviving in ATx normal mice had a rapid turnover and displayed an activated/memory phenotype, implying a chronic response to environmental antigens. Hence, in normal mice many gamma/delta RTEs did not die but switched to memory cells.

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I CorreaD Raulet
Nov 19, 1992·Nature·C A MichieP C Beverley
Apr 1, 1991·Immunological Reviews·L Van KaerS Tonegawa
May 1, 1991·The Journal of Experimental Medicine·D B AgusJ Sprent
Jan 1, 1990·International Immunology·K A Kelly, R Scollay
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M EgertonK Shortman
Oct 1, 1990·The Journal of Experimental Medicine·S R CardingP C Doherty
Aug 1, 1990·Immunology Letters·M HoW P Weidanz
Jul 1, 1990·The Journal of Infectious Diseases·C RoussilhonA Bensussan
Mar 1, 1990·The Journal of Experimental Medicine·C R MackayL Dudler
May 1, 1990·The Journal of Infectious Diseases·P De PaoliG Santini
Dec 1, 1985·The Journal of Experimental Medicine·J Sprent, M Schaefer
Jan 1, 1995·Annual Review of Immunology·S C JamesonM J Bevan
Apr 1, 1994·The Journal of Experimental Medicine·D F Tough, J Sprent
Jan 1, 1994·The Journal of Experimental Medicine·E P RockY H Chien
Sep 1, 1993·The Journal of Experimental Medicine·M J Skeen, H K Ziegler
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SpanerR A Phillips
Apr 1, 1993·The Journal of Experimental Medicine·H von Boehmer, K Hafen
Jan 1, 1993·Annual Review of Immunology·W HaasS Tonegawa
Apr 1, 1993·International Immunology·K A KellyR Scollay
May 1, 1996·The Journal of Experimental Medicine·E Schweighoffer, B J Fowlkes
Feb 1, 1997·Current Opinion in Immunology·R Boismenu, W L Havran
Jun 1, 1997·Current Opinion in Immunology·J Sprent
Aug 1, 1997·European Journal of Immunology·M J GaborR Scollay

❮ Previous
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Citations

Dec 16, 2000·Springer Seminars in Immunopathology·Z Yin, J Craft
Apr 3, 2002·The Journal of Experimental Medicine·Huji XuMichael F Good
Aug 6, 2003·The Journal of Experimental Medicine·Yunfei GaoZhinan Yin
Apr 19, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying-yi LuanZhi-yong Sheng
Oct 5, 2012·Journal of the Royal Society, Interface·Vitaly V Ganusov, Rob J De Boer
May 10, 2003·Proceedings. Biological Sciences·Rob J De BoerAlan S Perelson
Jul 20, 2011·Infection and Immunity·Cuixia ShiRalph C Budd
Aug 19, 2005·Molecular and Cellular Biology·Luca SimeoniBurkhart Schraven
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jena D FrenchRebecca L O'brien
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·F K KongM D Cooper
Jan 9, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·A Kalayciyan, Cc Zouboulis
Jan 15, 2013·Journal of Theoretical Biology·Rob J De Boer, Alan S Perelson
Feb 13, 2007·Immunological Reviews·Yueh-hsiu Chien, Yves Konigshofer
Feb 13, 2007·Immunological Reviews·Na Xiong, David H Raulet
Mar 22, 2005·Microbes and Infection·Elizabeth M Andrew, Simon R Carding
Nov 1, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Willi K BornRebecca L O'Brien
Feb 3, 2007·Molecular Immunology·Min ChenJin Wang
Oct 28, 2008·Burns : Journal of the International Society for Burn Injuries·Martin G Schwacha
Dec 6, 2017·Nature Communications·Terkild Brink BuusJens Peter Holst Lauritsen
Oct 4, 2003·Journal of Leukocyte Biology·Christina L RoarkRebecca L O'Brien
Nov 15, 2014·Journal of Leukocyte Biology·Pooja MehtaC Wayne Smith
Sep 20, 2006·European Journal of Immunology·Joanne E HolderWayne G Kimpton
Oct 26, 2010·Immunological Reviews·Dietmar J Kappes
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jena D FrenchRebecca L O'Brien
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S BonhoefferA S Perelson
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J B ReomeR W Dutton
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hae-ock LeeTerrence A Barrett
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen C De RosaMario Roederer
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kirk D C JensenYueh-Hsiu Chien
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shoji UeharaPaul E Love
Oct 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Na ZhaoZhinan Yin

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Methods Mentioned

BETA
transgenic

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