PMID: 11927211Apr 3, 2002Paper

Lifestyle and diet as risk factors for overanticoagulation

Journal of Clinical Epidemiology
Fernie J A Penning-van BeestBruno H C Stricker

Abstract

The risk of hemorrhage when using coumarin anticoagulants sharply increases when the International Normalized Ratio (INR) is > or =6.0. We performed a case-control study among outpatients of an anticoagulation clinic to identify sociodemographic-, lifestyle-, and dietary factors related to overanticoagulation. Three hundred cases with an INR > or =6.0 were compared with 302 randomly selected matched controls with an INR within the target zone. Age, sex, and level of education were not associated with overanticoagulation. Body mass index was negatively related to overanticoagulation, a beneath-average level of physical activity was positively related to overanticoagulation and never-smokers were more likely to have an INR > or =6.0 compared with smokers. Habitual alcohol consumption, even heavy drinking, was not related to overanticoagulation. However, a recent decrease of alcohol intake increased the risk of an INR > or =6.0. In addition, weight loss and a vacation were risk factors for overanticoagulation. Dietary factors were not associated with overanticoaguation. If risk factors can not be avoided, increased monitoring of INR values could prevent overanticoagulation and potential bleeding complications.

References

Jun 1, 1992·Annals of Internal Medicine·J H GurwitzJ Ansell
Jul 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Thomassen
Jan 1, 1990·Journal of Clinical Epidemiology·P A van den BrandtF Sturmans
Sep 1, 1989·The American Journal of Cardiology·J A BaronT Stukel
Oct 1, 1988·Lancet·P A KalraA M Holmes
Jan 1, 1985·Haemostasis·E A Loeliger, A W Broekmans
May 1, 1995·Journal of the American Dietetic Association·J E Harris
Jul 6, 1995·The New England Journal of Medicine·S C CannegieterE Briët
Jan 1, 1995·Journal of the American Dietetic Association·S L BoothJ A Sadowski
Mar 1, 1994·Human & Experimental Toxicology·D M HowarthI M Whyte
Jun 18, 1994·BMJ : British Medical Journal·J Slattery
Apr 1, 1994·Current Opinion in Pediatrics·M W Huysman, P J Sauer
Aug 22, 1996·The New England Journal of Medicine·F R Rosendaal
Jun 1, 1996·Clinical Pharmacokinetics·S Harder, P Thürmann
Aug 1, 1996·The British Journal of Nutrition·B L GijsbersC Vermeer
Mar 13, 1998·JAMA : the Journal of the American Medical Association·E M HylekD E Singer
May 20, 1998·European Journal of Clinical Pharmacology·U Klotz, E Ammon
Jun 3, 1998·British Journal of Haematology
Sep 2, 1998·European Journal of Clinical Nutrition·K Klipstein-GrobuschJ C Witteman
Oct 8, 1998·The Medical Journal of Australia·J Des Parkin, P J Thurlow
Dec 5, 1998·International Journal of Sports Medicine·A M CraciunC Vermeer
Jul 31, 1999·Clinical Pharmacokinetics·S Zevin, N L Benowitz

❮ Previous
Next ❯

Citations

Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Jul 12, 2005·Current Treatment Options in Cardiovascular Medicine·Edith A Nutescu, Cathy M Helgason
Jan 21, 2006·Journal of General Internal Medicine·Daniel P SchauerMark H Eckman
Dec 12, 2012·Pharmacogenomics·Rianne M F van SchieAnke-Hilse Maitland-van der Zee
Mar 14, 2007·Thrombosis Research·Angela Caduff Good, Samuel Henz
Mar 31, 2015·Revista Española De Cardiología·Manuel Anguita SánchezUNKNOWN CALIFA study researchers
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·T D Szucs, M Bramkamp
Sep 25, 2014·Pharmacoepidemiology and Drug Safety·Anton PottegårdJesper Hallas
Feb 16, 2010·British Journal of Haematology·Eva K RomboutsFelix J M van der Meer
Nov 19, 2014·Journal of Thrombosis and Haemostasis : JTH·Pascal M FreyDrahomir Aujesky
May 23, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pasquale PignatelliFrancesco Violi
Nov 14, 2015·Clinical Nutrition Research·Ji Na ParkMi-Kyung Sung
Jul 18, 2006·Thrombosis Research·Carl van WalravenAlan J Forster
Nov 21, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·F J Penning-van BeestB H Stricker
Jun 11, 2021·Annual Review of Nutrition·Michael S DanielsDiane L McKay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.