Lifestyle Changes in Young Adulthood and Middle Age and Risk of Cardiovascular Disease and All-Cause Mortality: The Doetinchem Cohort Study

Journal of the American Heart Association
Gerben HulseggeW M Monique Verschuren

Abstract

The associations between overall lifestyle profile and cardiovascular disease (CVD) and death have been mainly investigated in cross-sectional studies. The full benefits of a healthy lifestyle may therefore be underestimated, and the magnitude of benefits associated with changes in lifestyle remains unclear. We quantified the association of changes in lifestyle profiles over 5 years with risk of CVD and all-cause mortality. Lifestyle factors (ie, diet, physical activity, smoking, alcohol consumption) and body mass index were assessed and dichotomized as healthy/unhealthy among 5263 adults ages 26 to 66 in 1993-1997 and 5 years later (1998-2002). Multivariable-adjusted hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were estimated to quantify associations of change in lifestyle with fatal/nonfatal CVD and all-cause mortality that occurred 8 to 15 years after 1998-2002. Independent of baseline lifestyles, each decrement in number of healthy lifestyle factors was, on average, associated with 35% higher risk of CVD (HR, 1.35; 95% CI, 1.12-1.63) and 37% higher risk of all-cause mortality (HR, 1.37; 95% CI, 1.10-1.70); no association was noted with increase in the number of healthy lifestyle factors (P>0.5). Indi...Continue Reading

References

Dec 15, 1995·American Journal of Epidemiology·S Greenland, W D Finkle
Jan 1, 1997·International Journal of Epidemiology·M C OckéD Kromhout
May 29, 1998·International Journal of Epidemiology·M MulderW J van den Heuvel
Jul 7, 2000·The New England Journal of Medicine·M J StampferW C Willett
Apr 12, 2005·BMJ : British Medical Journal·Antonia TrichopoulouDimitrios Trichopoulos
Jul 13, 2006·Archives of Internal Medicine·Tobias KurthJulie E Buring
Jul 3, 2007·The American Journal of Medicine·Dana E KingMark E Geesey
Feb 2, 2008·International Journal of Epidemiology·W M M VerschurenH A Smit
Sep 18, 2008·BMJ : British Medical Journal·Rob M van DamFrank B Hu
May 20, 2009·Statistics in Medicine·Ian R White, Patrick Royston
May 18, 2010·Medicine and Science in Sports and Exercise·H Susan J PicavetW Monique M Verschuren
Jun 15, 2010·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Marieke P Hoevenaar-BlomW M M Verschuren
Jul 6, 2010·American Heart Journal·Jonathan A MitchellSteven N Blair
Feb 8, 2011·The American Journal of Medicine·Manuel FrancoValentín Fuster
Jun 18, 2011·Medicine and Science in Sports and Exercise·Barbara E AinsworthArthur S Leon
Jul 7, 2011·JAMA : the Journal of the American Medical Association·Stephanie E ChiuveChristine M Albert
Feb 16, 2012·European Heart Journal·Eri EguchiUNKNOWN Japan Collaborative Cohort Study Group
Oct 3, 2012·PloS One·Marieke P Hoevenaar-BlomW M Monique Verschuren
Jul 5, 2013·European Journal of Preventive Cardiology·Marieke P Hoevenaar-BlomW M Monique Verschuren
Jul 26, 2014·European Journal of Preventive Cardiology·Gerben HulseggeW M Monique Verschuren

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Citations

Aug 21, 2016·BMC Public Health·C KoopmanI van Dis
Mar 7, 2018·Public Health Nutrition·Lara Gomes SuhettJuliana Farias de Novaes
Apr 27, 2018·Scandinavian Journal of Medicine & Science in Sports·S PalomäkiT Tammelin
Apr 1, 2018·Journal of Epidemiology and Community Health·James WhiteG David Batty
Jun 28, 2019·BMJ : British Medical Journal·Alexander MokSoren Brage
Dec 7, 2019·BMJ Evidence-based Medicine·J David Spence
May 1, 2018·Teaching and Learning in Medicine·Andrew J HaleGrace C Huang
Nov 25, 2020·Heart·David W BakerRachael Cordina
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Zhecong YuLiqiang Zheng
May 22, 2021·Frontiers in Public Health·Hossain Syed AzfarKati Orru
Sep 1, 2021·JAMA Network Open·Laural K EnglishSteven B Heymsfield

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Methods Mentioned

BETA
MDS

Software Mentioned

R
SAS
R Foundation for Statistical Computing

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