Lifestyle-dependent brain change: a longitudinal cohort MRI study

Neurobiology of Aging
Regina Ey KimChol Shin

Abstract

We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49-79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.

Citations

Mar 22, 2019·Journal of the American College of Nutrition·Sunghee LeeChol Shin
Jan 11, 2019·Current Neurology and Neuroscience Reports·Corinne Pettigrew, Anja Soldan
Jun 3, 2020·Alzheimer Disease and Associated Disorders·Chol ShinRobert D Abbott
May 11, 2020·Brain, Behavior, and Immunity·K B CasalettoJ H Kramer
May 23, 2020·Neuroscience and Biobehavioral Reviews·Laura W M VergoossenMiranda T Schram
Jan 30, 2021·Journal of Geriatric Psychiatry and Neurology·Regina Eun Young KimChol Shin
Mar 17, 2021·Psychophysiology·Julian F ThayerJulian Koenig
May 27, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrei IrimiaHillard Kaplan
Dec 16, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Song E KimHyang Woon Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.