PMID: 12708727Apr 24, 2003Paper

Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women

Cancer Causes & Control : CCC
Naomi E AllenTimothy J Key

Abstract

This study aims to identify the lifestyle determinants of insulin-like growth factor-I (IGF-I) and its main binding proteins (IGFBPs), C-peptide, and sex hormone-binding globulin (SHBG) to help elucidate the mechanism through which lifestyle factors may affect cancer risk. This study is based on a sample of 292 British women, aged 20-70 years, whose lifestyle characteristics were assessed using a self-administered questionnaire and whose serum hormone concentrations were measured using immunoassays. Age was a strong determinant of both IGF-I and IGFBP levels; women aged 65-70 years had significantly lower IGF-I and IGFBP-3 concentrations and significantly higher IGFBP-1 and IGFBP-2 concentrations than women aged 20-24 years. Body mass index (BMI) was not strongly associated with IGF-I, although women with a BMI of 26-27.9 kg/m2 had a higher IGF-I concentration compared with both lean (BMI <20 kg/m2) and obese (BMI 30+ kg/m2) women. However, obese women had a significantly higher C-peptide and IGFBP-3 concentration and a significantly lower IGFBP-1, IGFBP-2, and SHBG concentration compared with lean women. Increasing vigorous exercise was associated with a significantly lower C-peptide concentration and increasing leisure-time a...Continue Reading

Citations

May 24, 2007·International Journal of Cancer. Journal International Du Cancer·Gertraud MaskarinecRudolph Kaaks
Oct 29, 2014·International Journal of Cancer. Journal International Du Cancer·Yin CaoEdward L Giovannucci
Mar 23, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I T GramR Kaaks
Jan 14, 2012·Obesity·Stefanie LiedtkeKaren Steindorf
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Jan 20, 2010·Cancer Causes & Control : CCC·Tianhui ChenAnnekatrin Lukanova
May 26, 2009·Arquivos brasileiros de endocrinologia e metabologia·Felipe Osório-CostaJosé B C Carvalheira
Jul 5, 2018·Nature Reviews. Gastroenterology & Hepatology·Neil MurphyMarc J Gunter
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Sjoerd G EliasPaulus A H Van Noord
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaRudolf Kaaks
Sep 9, 2004·British Journal of Cancer·A G RenehanS M Shalet
Jun 8, 2017·Breast Cancer Research and Treatment·Joy ShiKristan J Aronson
Mar 5, 2013·Breast Cancer Research and Treatment·Adana A LlanosPeter G Shields
Nov 26, 2020·The Journal of Clinical Endocrinology and Metabolism·Melissa K ThomasDeborah A Robins
Mar 21, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rehana L AhmedKathryn H Schmitz
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shelley S TworogerSusan E Hankinson
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Isabel dos Santos SilvaJulian Peto
Aug 1, 2016·Journal of the American Academy of Dermatology·Shekh Mohammad Amanur RahamanParul Kamboj
Jul 4, 2021·Cancer Causes & Control : CCC·Eleanor L WattsRuth C Travis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Deborah J ThompsonStudies in Epidemiology and Risks of Cancer Heredity Team
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Bruno MozzanegaSaula Vigili de Kreutzenberg
© 2022 Meta ULC. All rights reserved