Lifestyle interventions for adults with impaired glucose tolerance: a systematic review and meta-analysis of the effects on glycemic control

Internal Medicine
Qing-Hai GongGuo-Zhang Xu

Abstract

Previous meta-analyses have demonstrated that lifestyle modification can reduce the blood glucose levels in patients with type 2 diabetes, although the effects of changes in the blood glucose level on impaired glucose tolerance (IGT) remain controversial. This review therefore aimed to determine the efficacy of lifestyle interventions in adults with IGT. We searched the Medline, Cochrane Library, EMBASE and Science Citation Index databases and reference lists of the included articles. Two independent reviewers extracted the data and assessed the quality of the included studies; a total of nine randomized controlled trials met the inclusion criteria. In addition, we tested for trial heterogeneity and calculated the pooled effects size using the random effects model. The overall interventions were associated with a decline in the 2-hour plasma glucose levels [standardized mean differences (SMD) -0.56; 95% confidence interval (CI), -1.01 to -0.10; I(2), 96.6%]. Moreover, dietary intervention (SMD -0.53; 95% CI -0.77 to -0.28) and physical intervention (SMD -0.42; 95% CI -0.63 to -0.20) were each associated with a decline in the 2-hour plasma glucose levels compared with that observed in the control participants. The overall interv...Continue Reading

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Citations

Jul 30, 2016·International Journal of Behavioral Medicine·Brodie M SakakibaraJanice J Eng
Jul 23, 2016·Journal of Cellular Biochemistry·Afonso Kopczynski de CarvalhoAlexandre Pastoris Muller
Feb 22, 2017·Archives of Physical Medicine and Rehabilitation·Brodie M SakakibaraJanice J Eng
Jan 26, 2017·Medicine and Science in Sports and Exercise·Matthew McCarthyThomas Yates
Jun 23, 2016·Clinical Medicine Insights. Endocrinology and Diabetes·Wafaa AlSaggafJaakko Tuomilehto
May 26, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Arrigo Francesco Giuseppe CiceroClaudio Borghi
Nov 24, 2015·American Journal of Lifestyle Medicine·Karla I GalavizMary Beth Weber
Oct 23, 2020·Metabolic Syndrome and Related Disorders·Carla Haas PiovesanAna Maria Pandolfo Feoli
Dec 15, 2020·Frontiers in Public Health·Kaushik ChattopadhyayDorairaj Prabhakaran
Jan 26, 2021·The Journal of Nutrition, Health & Aging·C M T van der AvoortM T E Hopman

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