Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis

Obesity
Alan M PeacemanLIFE‐Moms Research Group

Abstract

This study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes. Seven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual-participant data meta-analysis. For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs. 75.0%; odds ratio [95% CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: -1.59 kg [95% CI:-2.18 to -0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight. Behavioral lifestyle interventions focusing ...Continue Reading

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Citations

Jan 31, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·T Cundy, R I G Holt
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Methods Mentioned

BETA
cesarean section

Clinical Trials Mentioned

NCT01545934
NCT01616147
NCT01771133
NCT01631747
NCT01768793
NCT01610752
NCT01812694

Software Mentioned

LIFE
SAS

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