Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Nature Reviews. Neurology
Miia KivipeltoTiia Ngandu

Abstract

Research into dementia prevention is of paramount importance if the dementia epidemic is to be halted. Observational studies have identified several potentially modifiable risk factors for dementia, including hypertension, dyslipidaemia and obesity at midlife, diabetes mellitus, smoking, physical inactivity, depression and low levels of education. Randomized clinical trials are needed that investigate whether interventions targeting these risk factors can reduce the risk of cognitive decline and dementia in elderly adults, but such trials are methodologically challenging. To date, most preventive interventions have been tested in small groups, have focused on a single lifestyle factor and have yielded negative or modest results. Given the multifactorial aetiology of dementia and late-onset Alzheimer disease, multidomain interventions that target several risk factors and mechanisms simultaneously might be necessary for an optimal preventive effect. In the past few years, three large multidomain trials (FINGER, MAPT and PreDIVA) have been completed. The FINGER trial showed that a multidomain lifestyle intervention can benefit cognition in elderly people with an elevated risk of dementia. The primary results from the other trials ...Continue Reading

References

Nov 13, 2002·JAMA : the Journal of the American Medical Association·Karlene BallUNKNOWN Advanced Cognitive Training for Independent and Vital Elderly Study Group
May 26, 2004·Lancet Neurology·Laura FratiglioniBengt Winblad
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Sherry L WillisUNKNOWN ACTIVE Study Group
Sep 12, 2007·Archives of Neurology·John HarrisonMichael Grundman
Oct 3, 2007·Neurology·T NganduM Kivipelto
Mar 6, 2008·Journal of Cellular and Molecular Medicine·Miia KivipeltoAulikki Nissinen
Apr 2, 2008·The New England Journal of Medicine·Nigel S BeckettUNKNOWN HYVET Study Group
Apr 19, 2008·Lancet Neurology·Bruno VellasUNKNOWN European Task Force Group
Aug 19, 2008·Neurobiology of Learning and Memory·Pirjo KomulainenRainer Rauramaa
Dec 9, 2008·Neurobiology of Aging·Suvi RovioMiia Kivipelto
Mar 31, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sophie Gillette-GuyonnetUNKNOWN MAPT Study Group
Jun 10, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L B HassingB Johansson
Jan 30, 2010·Journal of Alzheimer's Disease : JAD·Janine K CataldoStanton A Glantz
Mar 6, 2010·Acta Neuropathologica·Kurt A Jellinger, Johannes Attems
May 26, 2010·Nature Reviews. Neurology·Blossom C M StephanCarole Dufouil
Sep 10, 2010·Brain : a Journal of Neurology·Carol BrayneRaimo Sulkava
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Apr 14, 2011·Nature Reviews. Neurology·Natalie M ZahrClive G Harper
Jan 17, 2012·Neuroradiology·Yawu LiuUNKNOWN AddNeuroMed Consortium
Mar 10, 2012·Journal of the International Neuropsychological Society : JINS·Frederick W UnverzagtSharon L Tennstedt
Apr 12, 2012·Neurology·Robert S WilsonDavid A Bennett
Jul 31, 2012·Journal of Alzheimer's Disease : JAD·Anna-Maija TolppanenMiia Kivipelto
Nov 22, 2012·Translational Psychiatry·B M BrownUNKNOWN AIBL research group
Dec 5, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Hege Ihle-HansenBrynjar Fure
Jan 22, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miia KivipeltoHilkka Soininen
May 15, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Elena H Martínez-LapiscinaMiguel Á Martinez-Gonzalez
May 18, 2013·Epidemiology·Ilianna LouridaDavid J Llewellyn
Jun 12, 2013·Lancet·Kit Yee ChanUNKNOWN Global Health Epidemiology Reference Group (GHERG)
Jan 15, 2014·Biochemical Pharmacology·Bushra ImtiazHilkka Soininen
Mar 13, 2014·Journal of Internal Medicine·A SolomonM Kivipelto
Apr 12, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Anna-Maija TolppanenMiia Kivipelto
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings

❮ Previous
Next ❯

Citations

Dec 6, 2018·Menopause : the Journal of the North American Menopause Society·Pauline M Maki
Mar 12, 2019·Journal of the American Geriatrics Society·Erline E Martinez-MillerLaura F DeFina
Jul 17, 2019·ChemMedChem·Guilherme Martins SilvaCarlos Henrique Tomich de Paula da Silva
Aug 28, 2019·Journal of Alzheimer's Disease : JAD·Maria Skaalum PetersenSofus Joensen
Aug 28, 2019·Journal of Alzheimer's Disease : JAD·Stephanie FolleyElina Hyppönen
Aug 31, 2019·Journal of Clinical Psychology in Medical Settings·Martha ZimmermannCatalina Vechiu
Sep 29, 2019·Aging Cell·Antonio Di Meco, Domenico Praticò
Oct 30, 2019·Expert Opinion on Investigational Drugs·Bruno P Imbimbo, Mark Watling
Jan 23, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Garima SharmaMordhwaj S Parihar
Jun 7, 2019·Neurology·Gérard N Bischof, Heidi I L Jacobs
Apr 7, 2020·Molecular Psychiatry·Henrik Zetterberg, Barbara B Bendlin
Apr 14, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lezanne OoiRobert Williamson
Apr 3, 2020·Annals of Neurology·Rachel Buckley, Alvaro Pascual-Leone
Apr 25, 2020·Journal of Clinical Medicine·Patrick MüllerNotger G Müller
May 13, 2020·Journal of Neurochemistry·Guilherme B de FreitasFernanda G De Felice
Jul 7, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miia KivipeltoMaria C Carrillo
Jul 23, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Ben Lennox Kail, Dawn C Carr
Aug 21, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Giovanni B FrisoniCraig Ritchie
Jul 12, 2020·The Gerontologist·Flávia Borges-MachadoJoana Carvalho
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Jing WangXiaomei Li
Jul 19, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fernanda Leite, Laura Ribeiro
Nov 30, 2019·Journal of Global Health·Mario A ParraDavid J Robertson
Nov 19, 2019·Frontiers in Physiology·Thomas Gronwald, Henning Budde
Mar 17, 2020·Protein & Cell·Danyi LiJun Wang
Sep 6, 2020·Nature Reviews. Neurology·Sarah Lemprière
May 28, 2019·Frontiers in Molecular Neuroscience·Seham Alaiyed, Katherine Conant
May 22, 2019·Expert Review of Neurotherapeutics·Francesco PanzaBruno Pietro Imbimbo
Sep 26, 2019·Frontiers in Aging Neuroscience·Jaume FolchAntoni Camins

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy

Clinical Trials Mentioned

ISRCTN29711771
NCT01041989
NCT00672685

Software Mentioned

MAPT
PreDIVA

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.