Lifetime affective problems and later-life cognitive state: Over 50 years of follow-up in a British birth cohort study.

Journal of Affective Disorders
Sarah-Naomi JamesMarcus Richards

Abstract

Affective problems increase the risk of dementia and cognitive impairment, yet the life course dimension of this association is not clearly understood. We aimed to investigate how affective problems across the life course relate to later-life cognitive state. Data from 1269 participants from the Medical Research Council National Survey of Health and Development (NSHD, the British 1946 birth cohort) were used. Prospectively-assessed measures of affective symptoms spanning ages 13-69 and categorised into case-level thresholds. Outcomes consisted of a comprehensive measure of cognitive state (Addenbrooke's Cognitive Examination (ACE-III)), verbal memory, and letter search speed and accuracy at age 69. Complementary life course models demonstrated that having 2 or more case-level problems across the life course was most strongly associated with poorer cognitive outcomes, before and after adjusting for sex, childhood cognition, childhood and midlife occupational position and education. A disproportionate loss to follow-up of those who had lower childhood cognitive scores may have led to underestimation of the strength of associations. Using a population-based prospective study we provide evidence that recurrent lifetime affective pr...Continue Reading

Citations

Dec 5, 2019·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Antonios MougiasAntonios Politis
Dec 7, 2020·Brain : a Journal of Neurology·Shawn HayleyPaul R Albert
Mar 22, 2019·The British Journal of Psychiatry : the Journal of Mental Science·Amber JohnDarya Gaysina
Feb 20, 2021·Journal of Affective Disorders·Allen T C LeeLinda C W Lam
Feb 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Antoine SalzmannVictoria Garfield

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