PMID: 9424842Jan 10, 1998Paper

Lifetime diagnosis of prion transmissive encephalopathies

Voprosy virusologii
V M Roĭkhel'I A Zavalishin

Abstract

An original method for life-time diagnosis of Greutzfeldt-Jakob's disease, a neurodegenerative disease belonging to transmissive spongiform encephalopathies, is proposed. It consists in inoculation of the examined biological materials (blood serum and clot) into a continuous culture of the rat Gasser's node neurinoma, followed by passages and study of the inoculated culture by morphological methods and electron microscopy.

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