Lifetime presence of psychotic symptoms in bipolar disorder is associated with less favorable socio-demographic and certain clinical features

Comprehensive Psychiatry
Bernardo Dell'OssoA Carlo Altamura

Abstract

The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153). An overall less favorable socio-demographic profile was observed in BDPs vs BDNPs. In terms of clinical variables, BDPs vs BDNPs had: earlier age at onset (27.7±10.5 vs 30.1±12.3years; p=0.02), higher rates of BD I diagnosis (95.7% vs 45.8%; p<0.001), more elevated (manic/hypomanic/mixed) polarity of first (55.2% vs 24.4%; p<0.001) and most recent episode (69.8% vs 35.6%; p<0.001), more comorbid alcohol/substance use disorder (38.1% vs 21.9%; p=0.002), more lifetime hospitalizations (3.8±6.1 vs 2±3; p=0.002) and involuntary commitments (1±1.9 vs 0.1±0.4; p<0.001), more history of psychosocial rehabilitation...Continue Reading

Citations

Jan 20, 2019·The Australian and New Zealand Journal of Psychiatry·Alfredo Carlo AltamuraUNKNOWN ISBD Italian Chapter Epidemiological Group
Mar 25, 2019·CNS Spectrums·Massimiliano BuoliA Carlo Altamura
Dec 1, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Estela Jiménez-LópezJosé Luis Santos
Dec 17, 2019·International Journal of Bipolar Disorders·Francis BennettAditya N Sharma
Oct 13, 2017·Nordic Journal of Psychiatry·Gianluca SerafiniMario Amore
Aug 28, 2019·International Clinical Psychopharmacology·Laura CremaschiBernardo Dell'Osso
Aug 20, 2019·European Archives of Psychiatry and Clinical Neuroscience·Silvia TabanoMassimiliano Buoli
Sep 25, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Massimiliano BuoliUNKNOWN ISBD Italian Chapter Epidemiologic Group
Dec 7, 2018·Bipolar Disorders·Giorgio MarottaPaolo Brambilla

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