Abstract
Lifetime risk factors for cognitive and functional decline in Alzheimer's disease (AD) are not fully understood, and were prospectively evaluated in patients with low mean schooling from São Paulo, Brazil. Consecutive outpatients with late-onset AD were assessed for APOE haplotypes and the following potential baseline predictors: gender, schooling, age at dementia onset, lifetime urban living and sanitary conditions, occupational complexity, cognitive and physical activities, cerebrovascular risk factors (obesity, lifetime alcohol use and smoking, length of arterial hypertension, diabetes mellitus, and a dyslipidemic profile), use of a pacemaker, creatinine clearance, body mass index, waist circumference, head traumas with unconsciousness, treated systemic bacterial infections, amount of surgical procedures under general anesthesia, and family history of AD. Participants were followed from October 2010 to May 2017 for baseline risk factor associations with time since dementia onset for Clinical Dementia Rating and Mini-Mental State Examination score changes. For 227 patients (154 women, 119 APOE ε 4 carriers), later AD onset (mean 73.60±6.4 years-old, earlier for APOE ε 4/ε 4 carriers, p < 0.001) was the only variable hastening...Continue Reading
References
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Apr 4, 2000·Neurology·Z GuoL A Farrer
Dec 23, 2000·Dementia and Geriatric Cognitive Disorders·A RuitenbergM M Breteler
May 23, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M WinnockJ F Dartigues
Mar 14, 2003·Archives of Neurology·Nikolaos ScarmeasYaakov Stern
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Feb 26, 2005·Stroke; a Journal of Cerebral Circulation·Philip B Gorelick
Dec 29, 2005·Neurology·C A R MartinsJ H Williams
Feb 24, 2006·Alzheimer Disease and Associated Disorders·Alex E RoherThomas G Beach
May 10, 2006·Neurology·C CordonnierP Scheltens
Aug 1, 2006·Lancet·Kaj BlennowHenrik Zetterberg
Sep 7, 2007·Alzheimer Disease and Associated Disorders·Márcia Lorena Fagundes ChavesJeffrey Kaye
Jun 20, 2008·Vascular Health and Risk Management·E Duron, Olivier Hanon
Jan 13, 2009·Biochimica Et Biophysica Acta·Jarbas S Roriz-FilhoMatheus Roriz-Cruz
Apr 9, 2009·Journal of Neurology·Massimo MusiccoCarlo Caltagirone
Jun 13, 2009·Neuropsychobiology·Andréa DeslandesJerson Laks
Feb 4, 2010·Journal of the American Geriatrics Society·Julie A Schneider
Feb 18, 2011·Journal of Neurology·Kazumasa KumeToshihiko Iwamoto
Feb 25, 2011·Alzheimer Disease and Associated Disorders·Emily Joy RogalskiMarek-Marsel Mesulam
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Guy M McKhannCreighton H Phelps
Apr 17, 2012·Neurobiology of Aging·Camilla FerrariLaura Fratiglioni
Aug 8, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michelle A Erickson, William A Banks
Nov 6, 2013·Journal of the Neurological Sciences·Fabricio Ferreira de OliveiraMarilia de Arruda Cardoso Smith
Mar 7, 2014·International Journal of Geriatric Psychiatry·Fabricio Ferreira de OliveiraMarilia Cardoso Smith
Sep 10, 2014·JAMA Neurology·Adam C NajLei Yu
Jan 17, 2015·Neurology India·Fabricio Ferreira de OliveiraMarilia Cardoso Smith
Apr 4, 2015·Journal of Alzheimer's Disease : JAD·Fábio Henrique de Gobbi PortoSonia Maria Dozzi Brucki
May 8, 2015·Neurology·Galit WeinsteinCharles DeCarli
May 27, 2015·Clinical Neurology and Neurosurgery·Fabricio Ferreira de OliveiraMarilia Cardoso Smith
Aug 19, 2015·The Neurologist·Fabricio F OliveiraPaulo H F Bertolucci
Nov 3, 2015·Alzheimer Disease and Associated Disorders·Fabricio F OliveiraPaulo H F Bertolucci
Apr 23, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sharon K InouyeRichard N Jones
Jul 12, 2016·Dementia and Geriatric Cognitive Disorders·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci
Aug 18, 2016·JAMA Neurology·Giuseppe TostoUNKNOWN National Institute on Aging Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) Fam
Dec 16, 2016·Neurology·Kay DeckersSebastian Köhler
Jan 19, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Fabricio F de OliveiraPaulo H Bertolucci
Jan 19, 2017·The New England Journal of Medicine·Steven B Heymsfield, Thomas A Wadden
Feb 28, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jullyanna S M ShinosakiPaulo J Tannús
Mar 10, 2017·Neuroscience Letters·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci
Oct 17, 2017·Current Alzheimer Research·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci
Oct 25, 2017·The International Journal of Neuroscience·Fabricio Ferreira de OliveiraPaulo Henrique Ferreira Bertolucci
Nov 24, 2017·Neuroepidemiology·Ting ZhangYong Ji
Dec 12, 2017·Journal of Alzheimer's Disease : JAD·Camilla FerrariSandro Sorbi
Citations
Dec 14, 2018·Dementia & Neuropsychologia·Thais Sisti De Vincenzo SchultheiszAntonio de Pádua Serafim
Nov 14, 2018·American Journal of Physiology. Endocrinology and Metabolism·Joshua A KulasColin K Combs
Jan 7, 2020·Current Alzheimer Research·Peilin AnGuowei Huang
Sep 22, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Varinderpal S DhillonMichael Fenech
Aug 23, 2020·Molecular Neurobiology·Archna SharmaPing Wang
May 18, 2020·Journal of Alzheimer's Disease : JAD·Surya Prakash RaiJens Pahnke
Feb 27, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mario Alfredo ParraAgustin Ibanez
Oct 10, 2020·Current Alzheimer Research·Helene Karcher Alzheimer's Disease Neuroimaging Initiative
Nov 23, 2021·Frontiers in Aging Neuroscience·Morgan GautherotRenaud Lopes